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Cortisone acetate

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Cortisone acetate Basic information

Product Name:
Cortisone acetate
CAS:
50-04-4
MF:
C23H30O6
MW:
402.48
EINECS:
200-006-5
Mol File:
50-04-4.mol
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Cortisone acetate Chemical Properties

Melting point:
237-240 °C(lit.)
alpha 
D25 +164° (c = 0.5 in acetone); D25 +208 to +217° (dioxane)
refractive index 
212 ° (C=1, MeOH)
storage temp. 
2-8°C
solubility 
Practically insoluble in water, freely soluble in methylene chloride, soluble in dioxan, sparingly soluble in acetone, slightly soluble in ethanol (96 per cent) and in methanol.
form 
neat
Water Solubility 
19mg/L(25 ºC)
Merck 
14,2539
BRN 
2067543
Stability:
Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference
50-04-4(CAS DataBase Reference)
EPA Substance Registry System
Cortisone acetate (50-04-4)
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Safety Information

Safety Statements 
22-36/37-24/25
WGK Germany 
3
RTECS 
GM9140000
HS Code 
32041200

MSDS

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Cortisone acetate Usage And Synthesis

Chemical Properties

solid

Uses

Cortisone Acetate is a glucocorticoid. Cortisone Acetate is an antiinflammatory agent. Cortisone Acetate is bioavailable and readily converted to the therapeutically active form, Hydrocotisone (H71461 5).

General Description

Cortisone acetate, 21-(acetyloxy)-17-hydroxypregn-4-ene-3,11,20-trione, is the 21-acetate of naturally occurring cortisone with good systemicanti-inflammatory activity and low-to-moderate salt-retentionactivity after its in vivo conversion to hydrocortisoneacetate. This conversion is mediated by 11β-hydroxysteroiddehydrogenase. It is used for the entire spectrum of uses discussedpreviously under the heading, “Therapeutic Uses ofAdrenal Cortex Hormones”—collagen diseases, Addisondisease, severe shock, allergic conditions, chronic lymphocyticleukemia, and many other indications. Cortisone acetateis relatively ineffective topically, mainly because itmust be reduced in vivo to hydrocortisone. Its plasma halflifeis only about 30 minutes, compared with 90 minutes to3 hours for hydrocortisone.

Purification Methods

Crystallise -1cortisone-21-acetate from acetone or CHCl3. The UV has 15,800 M-1cm at 238nm in dioxane. [Sarett J Biol Chem 162 601 1946, Beilstein 8 III 4058, 5 IV 3481.]

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J & K SCIENTIFIC LTD.
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