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cis-1,2-Diaminocyclohexane

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cis-1,2-Diaminocyclohexane Basic information

Product Name:
cis-1,2-Diaminocyclohexane
CAS:
1436-59-5
MF:
C6H14N2
MW:
114.19
EINECS:
205-754-6
Mol File:
1436-59-5.mol
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cis-1,2-Diaminocyclohexane Chemical Properties

Melting point:
8°C
Boiling point:
92-93 °C18 mm Hg(lit.)
Density 
0.952 g/mL at 25 °C(lit.)
vapor pressure 
0.4 mm Hg ( 20 °C)
refractive index 
n20/D 1.493(lit.)
Flash point:
161 °F
form 
Low Melting Solid
pka
9.93(at 20℃)
color 
Brown
InChIKey
SSJXIUAHEKJCMH-OLQVQODUSA-N
CAS DataBase Reference
1436-59-5(CAS DataBase Reference)
NIST Chemistry Reference
cis-1,2-Cyclohexanediamine(1436-59-5)
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Safety Information

Hazard Codes 
C
Risk Statements 
34
Safety Statements 
26-36/37/39-45
RIDADR 
UN 2735 8/PG 2
WGK Germany 
3
10-34
HazardClass 
8
PackingGroup 
II
HS Code 
29213000

MSDS

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cis-1,2-Diaminocyclohexane Usage And Synthesis

Description

cis-1, 2-Diaminocyclohexane is a cyclohexane derivative. It can be used for the synthesis of platinum complexes with high antitumor activity. It can also be used for the preparation of multidentate ligands for uranyl and transition metal complexation. Moreover, it can also be used as the base for the manufacturing of titanium salalen catalyst. Its derivative also has the potential to be manufactured into a potent factor Xa inhibitor. 

References

Khokhar, Abdul R., et al. "Chemical and Biological Studies on a Series of Novel (trans-(1R,2R)-, trans-(1S,2S)-, and cis-1,2-Diaminocyclohexane)platinum(IV) Carboxylate Complexes." Journal of Medicinal Chemistry 40.1(1997):112.
Mauldin, S. K., et al. "High-performance liquid chromatographic separation of platinum complexes containing the cis-1,2-diaminocyclohexane carrier ligand. " Analytical Biochemistry157.1 (1986):129-43.
Berkessel, A, et al. "Titanium salalen catalysts based on cis-1,2-diaminocyclohexane: enantioselective epoxidation of terminal non-conjugated olefins with H2O2. " Angewandte Chemie 52.32(2013):8467-71.
Yoshikawa, K, et al. "Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part I: exploration of 5-6 fused rings as alternative S1 moieties. " Bioorganic & Medicinal Chemistry 17.24(2009):8221.
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Chemical Properties

Clear colorless liquid

Purification Methods

Dry the diamine over solid KOH and distil it in a vacuum. It is a strong base, keep away from CO2, store in the dark under N2. [Beilstein 13 IV 1.]

cis-1,2-Diaminocyclohexane Preparation Products And Raw materials

Raw materials

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TAIZHOU TIANHONG BIOCHEMICALS CO., LTD Gold
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400-660-8290 21-61259100-
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sh@meryer.com
Basic information Description References Safety Related Supplier