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Phenylmethylsulfonyl fluoride

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Phenylmethylsulfonyl fluoride Basic information

Product Name:
Phenylmethylsulfonyl fluoride
CAS:
329-98-6
MF:
C7H7FO2S
MW:
174.19
EINECS:
206-350-2
Mol File:
329-98-6.mol
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Phenylmethylsulfonyl fluoride Chemical Properties

Melting point:
92-95 °C
Boiling point:
112 °C16 mm Hg(lit.)
Density 
0.797 g/mL at 20 °C
Flash point:
222 °F
storage temp. 
2-8°C
solubility 
dry solvents (ethanol, methanol, and 2-propanol): 200 mM Stock solution are stable for months at 4°C.
form 
Needles (May Agglomerate)
color 
White
Water Solubility 
hydrolysis
Sensitive 
Moisture Sensitive
Merck 
14,7542
BRN 
2088311
InChIKey
YBYRMVIVWMBXKQ-UHFFFAOYSA-N
CAS DataBase Reference
329-98-6(CAS DataBase Reference)
EPA Substance Registry System
Benzenemethanesulfonyl fluoride (329-98-6)
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Safety Information

Hazard Codes 
F,T,C
Risk Statements 
11-34-25-23/24/25
Safety Statements 
7-16-45-36/37/39-28A-26-27
RIDADR 
UN 3261 8/PG 2
WGK Germany 
3
RTECS 
XT8050000
3-10-21
Hazard Note 
Highly Toxic/Corrosive
TSCA 
T
HazardClass 
8
PackingGroup 
III
HS Code 
29241990
Toxicity
LD50 (24 hr) in mice (mg/kg): 215 ±55 i.p. (Pinsky)

MSDS

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Phenylmethylsulfonyl fluoride Usage And Synthesis

Chemical Properties

White to cream solid

Uses

PMSF is an irreversible serine/cysteine protease inhibitor

Uses

Phenylmethylsulfonyl fluoride is used as a Protease inhibitor such as Chymotrypsin, Trypsin and Thrombin as well as Acetylcholineesterase.

Uses

Standard protease inhibitor in biological research; in protein purification to prevent proteolytic degradation.

Definition

ChEBI: An acyl fluoride with phenylmethanesulfonyl as the acyl group.

Purification Methods

Purify PMSF by recrystallisation from *C6H6, pet ether or CHCl3/pet ether. [Davies & Dick J Chem Soc 483 1932, cf Tullock & Coffman J Org Chem 23 2016 1960.] It is a general protease inhibitor (specific for trypsin and chymotrypsin) and is a good substitute for diisopropylphosphoro floridate [Fahrney & Gould J Am Chem Soc 85 997 1963]. [Beilstein 11 III 331.]

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Hunan Hui Bai Shi Biotechnology Co., Ltd. Gold
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sh@meryer.com
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