2-Nitrofluorene

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2-Nitrofluorene Basic information

Product Name:
2-Nitrofluorene
CAS:
607-57-8
MF:
C13H9NO2
MW:
211.22
EINECS:
210-138-5
Mol File:
607-57-8.mol
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2-Nitrofluorene Chemical Properties

Melting point:
156-158 °C(lit.)
Boiling point:
350.9°C (rough estimate)
Density 
1.1868 (rough estimate)
refractive index 
1.6060 (estimate)
form 
Powder
color 
White to brown
Water Solubility 
Insoluble
Stability:
Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference
607-57-8(CAS DataBase Reference)
NIST Chemistry Reference
Fluorene, 2-nitro-(607-57-8)
EPA Substance Registry System
2-Nitrofluorene (607-57-8)
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Safety Information

Hazard Codes 
Xn,N
Risk Statements 
40-51/53-68
Safety Statements 
36/37-61
RIDADR 
UN 3077 9/PG 3
WGK Germany 
3
RTECS 
LL8225000
TSCA 
Yes
HazardClass 
9
PackingGroup 
III
HS Code 
29042000
Hazardous Substances Data
607-57-8(Hazardous Substances Data)

MSDS

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2-Nitrofluorene Usage And Synthesis

Chemical Properties

cream powder

Definition

ChEBI: A nitroarene that is fluorene substituted by a nitro group at position 2.

General Description

Cream-colored solid.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Aromatic nitro compounds, such as 2-Nitrofluorene, range from slight to strong oxidizing agents. If mixed with reducing agents, including hydrides, sulfides and nitrides, they may begin a vigorous reaction that culminates in a detonation. The aromatic nitro compounds may explode in the presence of a base such as sodium hydroxide or potassium hydroxide even in the presence of water or organic solvents. The explosive tendencies of aromatic nitro compounds are increased by the presence of multiple nitro groups. Stable under normal conditions. Protect from bases.

Health Hazard

ACUTE/CHRONIC HAZARDS: Toxic. Hazardous decomposition products. Carcinogen.

Safety Profile

Confirmed carcinogen with experimental carcinogenic and tumorigenic data. Moderately toxic by intraperitoneal route. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also NITRO COMPOUNDS OF AROMATIC HYDROCARBONS.

Metabolic pathway

Lung microsomal metabolism of 2-nitrofluorene (NF) increases in parallel with the accumulation of P-450b homologous mRNA and microsomal cytochrome P- 450b protein concentration. The formation of the major metabolite, and potent mutagen, 9-hydroxy-2- nitrofluorene (9-OHNF) is significantly inhibited by the addition of polyclonal anti-P-450b-IgG, and by the addition of the inhibitor, proadifen, to incubations with lung microsomal protein.

Purification Methods

Crystallise 2-nitrofluorene from aqueous acetic acid or Me2CO (m 158-158.5o, also 160-160.5o). [Beilstein 5 H 628, 5 III 1948.]

2-Nitrofluorene Preparation Products And Raw materials

Preparation Products

Raw materials

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