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4-Chlorophenol

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4-Chlorophenol Basic information

Product Name:
4-Chlorophenol
CAS:
106-48-9
MF:
C6H5ClO
MW:
128.56
EINECS:
203-402-6
Mol File:
106-48-9.mol
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4-Chlorophenol Chemical Properties

Melting point:
40-45 °C(lit.)
Boiling point:
220 °C(lit.)
Density 
1.306 g/mL at 25 °C(lit.)
vapor density 
4.43 (vs air)
vapor pressure 
1 mm Hg ( 49.8 °C)
refractive index 
1.5579
Flash point:
240 °F
storage temp. 
0-6°C
solubility 
ethanol: soluble50mg/mL, clear to very slightly hazy, colorless to faintly brownish-yellow
pka
9.18(at 25℃)
form 
Low Melting Crystalline Mass
color 
White to pale yellow
Odor
Phenolic like 30 ppm
Odor Threshold
30 ppm
Water Solubility 
2.7 g/100 mL (20 ºC)
Sensitive 
Air Sensitive
Merck 
14,2154
BRN 
507004
Stability:
Stable. Incompatible with acid chlorides, acid anhydrides, oxidizing agents, iron.
CAS DataBase Reference
106-48-9(CAS DataBase Reference)
NIST Chemistry Reference
p-Chlorophenol(106-48-9)
EPA Substance Registry System
p-Chlorophenol (106-48-9)
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Safety Information

Hazard Codes 
Xn,N
Risk Statements 
20/21/22-51/53-50
Safety Statements 
28-61-28A-24/25-60-36/37
RIDADR 
UN 2020 6.1/PG 3
WGK Germany 
2
RTECS 
SK2800000
10-23
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
III
HS Code 
29081000
Hazardous Substances Data
106-48-9(Hazardous Substances Data)
Toxicity
LD50 orally in rats: 0.67 g/kg (Deichmann)

MSDS

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4-Chlorophenol Usage And Synthesis

Chemical Properties

off-white to light tan crystals or powder

Chemical Properties

All isomers have a characteristic odor.

Uses

Intermediates of Liquid Crystals

Uses

antineoplastic

Uses

Biocide; disinfectant for home, hospital and farm.

Definition

ChEBI: A monochlorophenol substituted at the pare position by a chlorine atom.

General Description

White crystals with a strong phenol odor Slightly soluble to soluble in water, depending on the isomer, and denser than water. Noncombustible. Used as an intermediate in organic synthesis of dyes and drugs.

Air & Water Reactions

Slightly soluble to soluble in water.

Reactivity Profile

CHLOROPHENOLS, SOLID are incompatible with acid chlorides, acid anhydrides and oxidizing agents. Also incompatible with iron . Liquefy and darken in color at temperatures above 108°F.

Hazard

Toxic by skin absorption, inhalation, or ingestion; strong irritant to tissue.

Health Hazard

Inhalation causes headache, dizziness, weak pulse. Ingestion causes irritation of mouth and stomach; headache, dizziness, weak pulse. Contact with eyes causes severe irritation and burning. Contact with skin causes irritation and burn; if absorbed, causes same symptoms as inhalation.

Fire Hazard

Special Hazards of Combustion Products: Toxic and irritating hydrogen chloride and chlorine gases may form in fires.

Safety Profile

Poison by inhalation and intraperitoneal routes. Moderately toxic by ingestion, skin contact, and subcutaneous routes. A severe skin and eye irritant. Human systemic effects by inhalation: excitement, irritability. Mutation data reported. Combustible when exposed to heat or flame. To fight fire, use water, spray, mist, fog, foam, dry chemical. When heated to decomposition it emits toxic fumes of Cl-. See also CHLOROPHENOLS and CHLORIDES.

Potential Exposure

Monochlorophenols are used in the manufacture of fungicides, slimicides, bactericides, pesticides, herbicides, disinfectants, wood and glue preservatives; in the production of phenolic resins; in the extraction of certain minerals from coal; as a denaturant for ethanol; as an antiseptic; as a disinfectant, and others.

Shipping

UN 2020 (solid); UN2021 (liquid) Chlorophenols, solid and liquid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

Purification Methods

Distil the phenol, then crystallise it from pet ether (b 40-60o) or hexane, and dry it under vacuum over P2O5 at room temperature. [Bernasconi & Paschalis J Am Chem Soc 108 2969 1986, Beilstein 6 IV 820.]

Incompatibilities

May form explosive mixture with air. Contact with oxidizing agents can cause fire and explosion hazard. Heat produces hydrogen chloride and chlorine. Corrosive to aluminum, copper and other chemically active metals.

Waste Disposal

Incinerate in admixture with flammable solvent in furnace equipped with afterburner and scrubber.

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4-ChlorophenolSupplierMore

Sigma-Aldrich Gold
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Shanghai Aladdin Bio-Chem Technology Co.,LTD Gold
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Suzhou LaiYue Biotechnology Co., Ltd. Gold
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Shanghai Qiao Chemical Science Co., Ltd Gold
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021-58892003-
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info@qiaochem.com;aaron@qiaochem.com
Qingdao Zhenguang Functional Materials Technology Co., Ltd. Gold
Tel:
16678624618 0532-66786246-
Email:
info@truelightchem.com
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