ChemicalBook >  Product Catalog >  Organic Chemistry >  Carboxylic acids and derivatives >  Carboxylic acid esters and derivatives >  Methyl cyanoacetate

Methyl cyanoacetate

Basic information Description Safety Related Supplier

Methyl cyanoacetate Basic information

Product Name:
Methyl cyanoacetate
CAS:
105-34-0
MF:
C4H5NO2
MW:
99.09
EINECS:
203-288-8
Mol File:
105-34-0.mol
More
Less

Methyl cyanoacetate Chemical Properties

Melting point:
-13 °C
Boiling point:
204-207 °C(lit.)
Density 
1.123 g/mL at 25 °C(lit.)
vapor density 
3.41 (vs air)
vapor pressure 
0.2 mm Hg ( 20 °C)
refractive index 
n20/D 1.417(lit.)
Flash point:
>230 °F
storage temp. 
Store below +30°C.
solubility 
54g/l
pka
2.75±0.10(Predicted)
form 
Liquid
color 
Clear colorless to very slightly yellow
Water Solubility 
54 g/L (20 ºC)
Sensitive 
Light Sensitive
BRN 
773945
CAS DataBase Reference
105-34-0(CAS DataBase Reference)
NIST Chemistry Reference
Acetic acid, cyano-, methyl ester(105-34-0)
EPA Substance Registry System
Acetic acid, cyano-, methyl ester (105-34-0)
More
Less

Safety Information

Hazard Codes 
Xi
Safety Statements 
24/25
RIDADR 
3276
WGK Germany 
1
RTECS 
AG4375000
Hazard Note 
Irritant
TSCA 
Yes
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29269095

MSDS

More
Less

Methyl cyanoacetate Usage And Synthesis

Description

Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It may be used in the synthesis of various 1,2,5-tricarbonyl compounds. It is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate; a compound used in the synthesis of DPP-IV inhibitors for treating type-2 diabetes. In addition, it is an intermediate in the preparation of α-cyanoacrylate, malononitrile, and 1,1-cyclohexanediacetic acid dyes. It is used as UV absorber or stabilizer, intermediate for pharmaceuticals. It may be used in the synthesis of various 1,2,5-tricarbonyl compounds.

Chemical Properties

clear colorless to very slighlty yellow liquid

Uses

pharmaceutical intermediate

Purification Methods

Purify the ester by shaking with 10% Na2CO3 solution, wash well with water, dry with anhydrous Na2SO4, and distil it. [Beilstein 2 H 584, 2 I 253, 2 II 530, 2 III 1628, 2 IV 1889.]

More
Less

Methyl cyanoacetateSupplierMore

Creasyn Finechem(Tianjin) Co., Ltd.
Tel:
022-83945878-
Email:
export@creasyn.com
J & K SCIENTIFIC LTD.
Tel:
010-82848833- ;010-82848833-
Email:
jkinfo@jkchemical.com;market6@jkchemical.com
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel:
21-61259100-
Email:
sh@meryer.com
future industrial shanghai co., ltd
Tel:
400-0066-400;021-60496031
Email:
sales@jonln.com
Alfa Aesar
Tel:
400-610-6006; 021-67582000
Email:
saleschina@alfa-asia.com
Basic information Description Safety Related Supplier