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Dexamethasone-17-acetate

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Dexamethasone-17-acetate Basic information

Product Name:
Dexamethasone-17-acetate
CAS:
1177-87-3
MF:
C24H31FO6
MW:
434.5
EINECS:
214-646-8
Mol File:
1177-87-3.mol
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Dexamethasone-17-acetate Chemical Properties

Melting point:
238-240 °C(lit.)
alpha 
D25 +73° (chloroform) (Arth, 1958); D +77.6° (Oliveto)
Boiling point:
579.4±50.0 °C(Predicted)
Density 
1.1517 (estimate)
refractive index 
87 ° (C=1, Dioxane)
storage temp. 
2-8°C
solubility 
Soluble at 100 mg/ml in acetone
pka
12.08±0.70(Predicted)
form 
Powder
color 
White
Water Solubility 
13mg/L(25 ºC)
Merck 
2943
BRN 
2342608
CAS DataBase Reference
1177-87-3(CAS DataBase Reference)
NIST Chemistry Reference
Prednisolone, 9alpha-fluoro-16alpha-methyl-, acetate(1177-87-3)
EPA Substance Registry System
Dexamethasone-21-acetate (1177-87-3)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
43
Safety Statements 
36/37
WGK Germany 
3
RTECS 
TU4050000
TSCA 
Yes
HS Code 
29372290

MSDS

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Dexamethasone-17-acetate Usage And Synthesis

Chemical Properties

Off-White Solid

Uses

Protected Dexamethasone, a glucocorticoid anti-inflammatory agent.

brand name

Decadron (Merck).

Safety Profile

Experimental teratogenic and reproductive effects. A steroid. When heated to decomposition it emits toxic fumes of F-.

Purification Methods

Dexamethasone 21-acetate is purified on neutral Al2O3 using CHCl3 as eluent, the fractions are evaporated, and the residue is recrystallised from CHCl3. It has max at 239nm. [Oliveto et al. J Am Chem Soc 8 0 4431 1958]. [Beilstein 8 IV 3501.]

Dexamethasone-17-acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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