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Monensin

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Monensin Basic information

Product Name:
Monensin
CAS:
17090-79-8
MF:
C36H61NaO11
MW:
692.85
EINECS:
241-154-0
Mol File:
17090-79-8.mol
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Monensin Chemical Properties

Melting point:
103-105°C
alpha 
D +47.7°
Boiling point:
608.24°C (rough estimate)
Density 
1.0773 (rough estimate)
refractive index 
1.5465 (estimate)
storage temp. 
2-8°C
pka
6.6 (in 66% DMF)
CAS DataBase Reference
17090-79-8(CAS DataBase Reference)
EPA Substance Registry System
Monensin (17090-79-8)
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Safety Information

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
36/37/39-45
RIDADR 
UN 3462 6.1/PG 2
WGK Germany 
3
RTECS 
JH2830000
HazardClass 
6.1(a)
PackingGroup 
II
Hazardous Substances Data
17090-79-8(Hazardous Substances Data)
Toxicity
LD50 of monensin complex in mice, chicks (mg/kg): 43.8 ± 5.2, 284 ± 47 orally (Haney, Hoehn)
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Monensin Usage And Synthesis

Chemical Properties

Crystallin Solid

Uses

Monensin A is a polyether antibiotic first isolated from Streptomyces cinnamonensis in 1967. Monensin A is a broad-spectrum anticoccicidial antibiotic, also exhibiting antifungal and antiviral activity. Monensin A forms complexes with monovalent cations such as Li+, Na+, K+, Rb+, Ag+ and Tl+ and is thus able to transport these cations across lipid membranes of cells, playing an important role as an Na+/H+ antiporter. It blocks intracellular protein transport and is used in animals to prevent coccidiosis, promote growth and prevent bloat. Derivatives of monensin, monensin methyl ester and particularly monensin decyl ester, are used in ion selective electrodes.

Uses

Poliether antibiotic. Coccidiostat

Uses

Monensin (2) C36H62O11, a carboxylic acid which is used as its water-soluble sodium salt (Coban, Rumensin). Monensin is also used to treat histomoniasis. The polyether ionophoric antibiotics are capable of complexing and interfacing with specific alkali metal cations to render them lipid-soluble and diffusible across parasite mitochondrial membranes. Related useful polyether antibiotics are narasin and lasalocid (3, Lasalocid A, C34H54O8,).

brand name

Coban [as sodium salt] (Lilly);Rumensin [as sodium salt] (Lilly).

Safety Profile

Poison by ingestion and intraperitoneal routes. An eye and skin irritant. When heated to decomposition it emits acrid smoke and irritating fumes.

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MonensinSupplierMore

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel:
18930552037 821-50328103-801
Email:
3bsc@sina.com
BEST-REAGENT
Tel:
18981987031 400-1166-196
Email:
cdhxsj@163.com;1955352637@qq.com;cdhxsj@163.com
BOC Sciences
Tel:
16316197922
Email:
info@bocsci.com
Chengdu Biopurify Phytochemicals Ltd.
Tel:
18080487181 028-82633397
Email:
sales03@biopurify.com
Nanjing Sunlida Biological Technology Co., Ltd.
Tel:
025-58378339
Email:
sales@sunlidabio.com;sales@sunlidabio.com
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