粉蝶霉素A
粉蝶霉素A 性质
| 沸点 | 614.9±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.044±0.06 g/cm3(Predicted) |
| 闪点 | 85 °C |
| 储存条件 | 2-8°C |
| 溶解度 | 可溶于DMSO（高达25mg/ml）或乙醇（高达20mg/ml）。 |
| 酸度系数(pKa) | 5.21±0.33(Predicted) |
| 形态 | 液体 |
| 颜色 | 黄绿色 |
| 稳定性 | 自购买之日起 2 年内保持稳定。 DMSO 或乙醇溶液可在 -20°C 下保存长达 1 个月。 |
粉蝶霉素A 用途与合成方法
In a cell free assay, the potency of Piericidin A to inhibit mitochondrial complex I is ∼2 fold smaller than the one of annonacin. In cultured neurons, Piericidin A potently induces the redistribution of phosphorylated tau from the dendrites into the cell soma and induces cell death.
The viability of Tn5B1-4 cells is inhibited by Piericidin A in a time- and concentration-dependent manner with IC
50
value of 0.061 μM, whilst Piericidin A shows slight inhibitory effect on the viability of HepG2 and Hek293 cells with IC
50
value of 233.97 μM and 228.96 μM, respectively. Piericidin A induces apoptosis of Tn5B1-4 cells coincides with a decrease in the mitochondrial membrane potential.
Piericidin A (0.5 mg/kg/d; for 28 days via osmotic minipumps) significantly increases the number of phospho-tau immunoreactive cells in the cerebral cortex in P301S +/+ mice. Piericidin A leads to increased levels of pathologically phosphorylated tau only in P301S +/+ mice. The synaptic density is reduced by Piericidin A treatment in P301S +/+ mice. Exposure to Piericidin A aggravates the course of genetically determined tau pathology.
安全信息
| 危险品标志 | T+,Xn |
|---|---|
| 危险类别码 | 26/27/28-20/21/22 |
| 安全说明 | 28-36/37-45 |
| 危险品运输编号 | UN 3382 6.1/PG 1 |
| WGK Germany | 3 |
| RTECS号 | YD4588000 |
| F | 3-10 |
| 海关编码 | 2933399990 |
粉蝶霉素A 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-01-25 | HY-114936 | 粉蝶霉素A | 2738-64-9 | 1mg(12.03mM * 200μL in Ethanol) | 4500 |
