Aglepristone is used as a treatment to induce parturition in ewes and their newborns. A competitive progesterone antagonist for treatment of various progesterone-dependent physiology and pathology conditions, and effective means of terminating pregnancy in most species. Also, it prevents sperm progression toward the oviducts and fertilization in inseminated females.
ChEBI: Aglepristone is an oxo steroid.
Veterinary Drugs and Treatments
Aglepristone is labeled (in the U.K. and elsewhere) for pregnancy
termination in bitches up to 45 days after mating.
In dogs, aglepristone may prove useful in inducing parturition
or treating pyometra complex (often in combination with a prostaglandin
F analog such as cloprostenol).
In cats, it may be of benefit for pregnancy termination (one
study documented 87% efficacy when administered at the recommended
dog dose at day 25) or in treating mammary hyperplasias
or pyometras.
