Aflatoxin B1 (AFB1) is a Class 1A carcinogen, which is a secondary metabolite of Aspergillus flavus and A. parasiticus. Aflatoxin B1 (AFB1) mainly induces the transversion of G-->T in the third position of codon 249 of the p53 tumor suppressor gene, resulting in mutation[1][2].
Related Catalog
Research Areas >> Cancer
Signaling Pathways >> Others >> Others
Target
Human Endogenous Metabolite
References
[1]. Gizachew D, et al. Aflatoxin B1 (AFB1) production by Aspergillus flavus and Aspergillus parasiticus on ground Nyjer seeds: The effect of water activity and temperature. Int J Food Microbiol. 2019 May 2;296:8-13.
[2]. Aguilar F, et al. Aflatoxin B1 induces the transversion of G-->T in codon 249 of the p53 tumor suppressor gene in human hepatocytes. Proc Natl Acad Sci U S A. 1993 Sep 15;90(18):8586-90.
Chemical & Physical Properties
Density
1.6±0.1 g/cm3
Boiling Point
528.2±50.0 °C at 760 mmHg
Melting Point
268-269 °C
Molecular Formula
C17H12O6
Molecular Weight
312.274
Flash Point
237.7±30.2 °C
Exact Mass
312.063385
PSA
74.97000
LogP
0.45
Vapour Pressure
0.0±1.4 mmHg at 25°C
Index of Refraction
1.687
MSDS
AFLATOXIN B1 MSDS(Chinese)
Safety Information
Symbol
GHS06, GHS08
Signal Word
Danger
Hazard Statements
H300 + H310 + H330-H350
Precautionary Statements
P201-P260-P264-P280-P284-P301 + P310
Personal Protective Equipment
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Literature: Trost, Barry M.; Toste, F. Dean Journal of the American Chemical Society, 2003 , vol. 125, # 10 p. 3090 - 3100
9,10-Anthracene...
CAS#:10254-99-6
~%
AFLATOXIN B1
CAS#:1162-65-8
Literature: Journal of the American Chemical Society, , vol. 120, # 25 p. 6231 - 6239
O-methylsterigm...
CAS#:30361-73-0
~%
AFLATOXIN B1
CAS#:1162-65-8
Literature: Journal of Organic Chemistry, , vol. 59, # 16 p. 4424 - 4429
Articles123
More Articles
Low toxicity of deoxynivalenol-3-glucoside in microbial cells.
Toxins (Basel.) 7(1) , 187-200, (2015)
Host plants excrete a glucosylation enzyme onto the plant surface that changes mycotoxins derived from fungal secondary metabolites to glucosylated products. Deoxynivalenol-3-glucoside (DON3G) is synt...
Aflatoxins contamination in Pakistani brown rice: a comparison of TLC, HPLC, LC-MS/MS and ELISA techniques.
Toxicol. Mech. Methods 24(8) , 544-51, (2014)
Advancement in the field of analytical food-chemistry has explored various experimental techniques for aflatoxins (AFs) quantification. The present study was aimed to compare four different techniques...
Deoxynivalenol-mimic nanobody isolated from a naïve phage display nanobody library and its application in immunoassay.
Anal. Chim. Acta 887 , 201-8, (2015)
In this study, using mycotoxin deoxynivalenol (DON) as a model hapten, we developed a nanobody-based environmental friendly immunoassay for sensitive detection of DON. Two nanobodies (N-28 and N-31) w...
Henan Fengda Chemical Co., Ltd. is located in the High-tech Development Zone of Henan Province. Specializing in the production and sales of various fine chemical products required for industrial production, including chemical raw materials, organic raw materials, petrochemicals, chemical reagents, solvents, catalysts, and additives, etc.
China
