4-Chloro-o-phenylenediamine NEW

• DATA ITEMS CITED :

• 28

• MOLECULAR FORMULA :

• C6-H7-Cl-N2

• MOLECULAR WEIGHT :

• 142.60

• WISWESSER LINE NOTATION :

• ZR BZ DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 135 gm/kg/77W-C

• TOXIC EFFECTS :

• Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - tumors

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 324 gm/kg/77W-C

• TOXIC EFFECTS :

• Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

• TYPE OF TEST :

• TD - Toxic dose (other than lowest)

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 273 gm/kg/78W-C

• TOXIC EFFECTS :

• Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Kidney, Ureter, Bladder - tumors

• TYPE OF TEST :

• TD - Toxic dose (other than lowest)

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 917 gm/kg/78W-C

• TOXIC EFFECTS :

• Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

• TYPE OF TEST :

• TD - Toxic dose (other than lowest)

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 136 gm/kg/78W-C

• TOXIC EFFECTS :

• Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Kidney, Ureter, Bladder - tumors

• TYPE OF TEST :

• TD - Toxic dose (other than lowest)

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 460 gm/kg/78W-C

• TOXIC EFFECTS :

• Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

• TYPE OF TEST :

• TD - Toxic dose (other than lowest)

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 40500 gm/kg/96W-C

• TOXIC EFFECTS :

• Tumorigenic - neoplastic by RTECS criteria Liver - tumors

• TYPE OF TEST :

• TD - Toxic dose (other than lowest)

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 18750 gm/kg/2Y-C

• TOXIC EFFECTS :

• Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - tumors

• TYPE OF TEST :

• Micronucleus test

• TYPE OF TEST :

• Cytogenetic analysis

MUTATION DATA

• TEST SYSTEM :

• Rodent - mouse

• DOSE/DURATION :

• 400 mg/kg

• REFERENCE :

• EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 14,207,1989 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 27,81,1982 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 27,81,1982 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-FINLAND;Carcinogen JAN 1993 OEL-FRANCE;Carcinogen JAN 1993