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| Common Name | Guanidine hydrochloride |
|---|
| CAS Number | 50-01-1 | Molecular Weight | 95.531 |
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| Density | 1.18 g/mL at 25 °C(lit.) | Boiling Point | 132.9ºC at 760 mmHg |
|---|
| Molecular Formula | CH6ClN3 | Melting Point | 180-185 °C(lit.) |
|---|
| MSDS | ChineseUSA | Flash Point | N/A |
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| Symbol | 
GHS07 | Signal Word | Warning |
|---|
Use of Guanidine hydrochloride
Guanidine HCl, the crystalline compound of strong alkalinity formed by the oxidation of guanine, is a normal product of protein metabolism and a protein denaturant.Target: OthersGuanidine HCl is the most popular protein denaturant. Analysis of unfolding transitions by Guanidine HCl provides several important parameters regarding the mechanism of conformational stability of proteins. Guanidine HCl at low concentrations refolds acid-unfolds apomyoglobin and cytochrome c, stabilizing the molten globule state. Guanidine HCl (> 1 M) causes co-operative unfolding of the molten globule state [1]. Guanidine HCl at millimolar concentrations, is able to causes efficient loss of the normally stable [PSI+] element from yeast cells. 5 mM Guanidine HCl in growth media cures [PSI+] and other prions of yeast. 5 mM Guanidine HCl significantly reduces Hsp104-mediated basal and acquired thermotolerance by 30-fold and 50 fold, respectively. Guanidine HCl also reduces the ability of Hsp104 to restore activity of thermally denatured luciferase [2].
Chemical & Physical Properties
| Density | 1.18 g/mL at 25 °C(lit.) |
|---|
| Boiling Point | 132.9ºC at 760 mmHg |
|---|
| Melting Point | 180-185 °C(lit.) |
|---|
| Molecular Formula | CH6ClN3 |
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| Molecular Weight | 95.531 |
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| Exact Mass | 95.025024 |
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| PSA | 75.89000 |
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| LogP | 1.14090 |
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| Index of Refraction | n20/D 1.465 |
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| Storage condition | Store at RT. |
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| Stability | Stable. Hygroscopic. Incompatible with strong oxidizing agents. |
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| Water Solubility | 2280 g/L (20 ºC) |
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Synonyms
| ZYZUM &&HCl |
| Guanidine hydrochloride (1:1) |
| guanidinium chloride |
| Guanidine, hydrochloride (1:1) |
| Guanidine monohydrochloride |
| Amino(imino)methanaminium chloride |
| GdmCl |
| Guanidine (hydrochloride) |
| guanidine chlorhydrate |
| hydrochloric acid guanidine |
| Aminoformamidine hydrochloride,Aminomethanamidine hydrochloride,Guanidinium chloride |
| Guanidine Hydrochlor |
| Guanidine chloride |
| Aminoformamidine hydrochloride |
| GUANIDIUM CHLORIDE |
| GUHY |
| Aminoformamidine hydrochloride,Guanidinium chloride,Guanidium chloride |
| 1-methylguanidine hydrochloride |
| Aminomethanamidine hydrochlorid |
| MFCD00013026 |
| AMINOFORMAMIDINE HCL |
| Guanidinehydrochloride |
| Guanidine, monohydrochloride |
| usafek-749 |
| EINECS 200-002-3 |
| Guanidinhydrochlorid |
| Guanidine Hydrochloride |
| Guanidine HCl |
| guanidinium hydrochloride |
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