Nimesulide properties
Fusing point
140-146°C
Boiling point
442.0 + / - 55.0 ° C (Predicted)
density
1.451 + / - 0.06 g/cm3 (Predicted)
Storage condition
2-8°C
solubility
Almost insoluble in water, easily soluble in acetone, slightly soluble in anhydrous ethanol.
Acidity coefficient
(pKa) pKa6.56 + / - 0.03 (H2O, t = 25, I = 0.02) (Approximate)
colour
Light orange to yellow to green
Water solubility
Solubleinwater(<50µ G/ml), 1:10 DMSO: PBS (pH7.2 (< 200 & # 181; g/ml),ethanol(1mg/ml),DMSO
(15mg/ml),DMF(15mg/ml),chloroform,dichloromethane,acetone(freelysoluble),and1NNaOH. Maximum
wavelength (λmax)391nm(H2O)(lit.)Merck14,6548
stability
It's stable. Incompatible with strong oxidants.
InChIKey:
HYWYRSMBCFDLJT-UHFChemicalbookFFAOYSA-N
EPA Chemical Information:
Methanesulfonamide,N-(4-nitro-2-phenoxyphenyl)-(51803-78-2)
Use and synthesis of Nimesulide
intro
Nimesulide is a non-steroidal anti-inflammatory drug with anti-inflammatory, analgesic and antipyretic effects.
Listed in China in 1997, Nimesulide has been listed in the product dosage forms including tablets, capsules,
granules, dry suspension, gel. The original approved indications were for the treatment of symptoms such as
chronic arthritis, pain and inflammation after surgery and acute trauma, and fever due to upper respiratory
infections.
Pharmacological action
Nimesulide is a non-steroidal anti-inflammatory drug with anti-inflammatory, analgesic and antipyretic effects.
The mechanism may be related to inhibition of prostaglandin synthesis, leukocyte release and oxidation of
polymorphonuclear leukocytes.
pharmacokinetics
Oral administration of the drug absorption is rapid and complete, widely in the body and plasma protein binding,
free drugs only 0.7% to 4.0%. It is mainly distributed in the extracellular fluid, and the metabolites in the liver are
mainly 4-hydroxyl derivatives, which are excreted from the urine and feces, and the half-life of drug elimination is
1.96 ~ 4.73h
China
