Chinese name: Tekotide
English name :Cosyntropin
CAS:16960-16-0
EINECS number :241-031-1
Molecular formula :C28H55NO
MDL number :MFCD00167476
Molecular weight :421.74
Appearance: This product is a synthetic 24 peptide corticotropin analogue. The sequence of amino acids is the same as the 24 amino acids of the amino end of natural corticotropin (human, bovine, pig), and has the same physiological activity as natural ACTHm. The most prominent feature is that there is generally no antibody reaction, no serious side effects, especially suitable for patients who have allergic reactions to natural porcine corticotropin or ineffective.
The effect of 1ml of this product is equivalent to 100 units of natural corticotropin. This product is not effective orally. After intravenous injection, the concentration of cortisol in the blood increased rapidly and disappeared from the blood about 30 minutes. The blood concentration reached the maximum at 1h intramuscular injection, and the effect could be maintained for more than 4h.
Density :1.47± 0.1g /cm3(Predicted)
Storage condition :−20°C
Solubility: slightly soluble in water.
Form: solid
Water solubility: Soluble in water
Sequence: H-ser-tyr-ser-met-glu-his-phit-arg-trp-gly-lys-pro-val-gly-lys-arg-arg-pro-val-lys-val-tyr-pro-OH
Stability: hygroscopicity
InChIKey:ZOEFCCMDUURGSE-SQKVDDBVSA-N
category
Biochemicals: Peptides and proteins: corticotropin and its derivatives
use
For the diagnosis of adrenal cortical insufficiency; It can also be used to treat rheumatism, rheumatoid arthritis, skin diseases and so on.
China
