Azido-dPEG<SUP>?</SUP><SUB>4</SUB>-acid,1257063-35-6

聚合物结构设计

shape: linear
functionality: heterobifunctional

特点和优势

The azido-dPEG?4 contains an azide function on one end of a single molecular weight dPEG? spacer (17.7 ?) and a reactive group on the other end of the spacer. The dPEG? spacer is hydrophilic and non-immunogenic and improves the water solubility of the target molecule while reducing the immunogenicity and increasing the hydrodynamic volume of the target. The acid function may be activated with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) or N,N′-dicyclohexylcarbodiimide (DCC) for conjugation to an amine. The azide group reacts with an alkyne in the well-known click chemistry reaction. The click chemistry reaction proceeds by copper(I) or ruthenium catalysis or in a strain-catalyzed reaction with certain types of alkyne partners.