Claudin-18.2重组蛋白，ACROBiosystems百普赛斯

Claudin-18.2产品信息

英文名称：Claudin-18 splice variant 2

中文名称：密蛋白-18剪接变体2

靶点别称：Claudin-18.2、CLDN18、Claudin-18

物种：Human / Mouse / Cynomolgus

属性：Protein / Antibody / Kits / Cell / Licensing / Antibody Licensing

标记：Biotin-labeled / Unconjugated / GFP Fusion

内毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

制剂（Formulation）

The VLPs are highly immunogenic, so the immunization strategy should be optimized (antigen dose, regimen and adjuvant).

Supplied as 0.2 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

运输（Shipping）

This product is supplied and shipped with dry ice, please inquire the shipping cost.

存储（Storage）

Please protect from light and avoid repeated freeze-thaw cycles.

This product is stable after storage at:

1. The product MUST be stored at -70°C or lower upon receipt;

2. -70°C for 12 months under sterile conditions.

Claudin-18.2分子背景

Claudins (CLDNs) are a family of proteins that form tight junctions and maintain the polarity of epithelial and endothelial cells. CLDN18 is specifically expressed in the stomach and lung. Of the two CLDN18 isoform transcripts produced by alternative splicing, CLDN18.2 is a highly selective gastric lineage marker that determines the gastric phenotype in a neoplastic condition, whereas CLDN18.1 is lung specific. CLDN18.2 is a highly selective gastric lineage antigen expressed exclusively on short-lived differentiated gastric epithelial cells where it has only limited accessibility to antibody drugs.14,15 CLDN18.2 is maintained during the course of malignant transformation and thus frequently displayed on the surface of human gastric cancer cells.

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