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Toxicity of lsobornyl acetate

Dec 9，2021

Isobornyl Acetate appears clear liquid, has flesh and woody odor character, Camphor like smell. Sulfuric acid as the catalyst for prepared from Camphene with Acetic acid. Isobornyl Acetate is used for fragrance formula of soaps, cleaning and other household products.

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Metabolism and Pharmacokinetics

lsobornyl acetate readily hydrolyzes (within hours) to isobornyl alcoholduring the first step of it biochemical pathway. The alcohol will become conjugated with glucuronic acid and be excreted in the urine (expected withinhours to days). (JEFCA 2006)Overall,JEFCA(2005a) expects that isobornylacetate will be metabolized to innocuous products.

Use

lsobornyl acetate is important as a flavoring agent and in industries where scenting is necessary (e.g., manufacture of toiletries) as it provides a pine-needle odor. As an inert ingredient in pesticide formulations, isobornyl acetate is used as a solvent in pesticide products that are used on agricultural crops.

List Reclassification Determination

The current List Classification for isobornyl acetate is List 3. Because EPA has determined that there is a reasonable certainty that no harm to any population subgroup will result from aggregate exposure to isobornyl acetate used as an inert ingredient in pesticide formulations, the List Classification will change from List 3 to List 48.

Toxicity

lsobornyl acetate has low oral and dermal acute toxicity (Toxicity Category lV).In a subchronic oral study, the "principal untoward effect of [isobornyl acetate] was onthe kidney, especially in male animals;"nephrotoxicity was seen as low as 90mg/kg/day(Gaunt et al 1971). The kidney effects were only seen in the male rats. Apossible explanation for the nephrotoxic effects in males but not females is the accumulation of alpha-2u-globulin, a protein in the male rat kidney that appears to leadto renal tubule tumor formation (Us EPA 1991).

Female rats and other laboratory mammals administered the same chemicals do not accumulate it in the kidney and theydo not develop renal tubule tumors (US EPA 1991).The no effect level reported fromthis subchronic study—15 mg/kg/day—is a dose much greater than would be expectedfrom any potential food or drinking water exposure.Developmental toxicity data are notavailable for isobornyl acetate, per se. However, the developmental toxicity data forcamphor--a closely related chemical--show no effects in the offspring, even at doseswhere effects were seen in the maternal animals (i.e., no increased sensitivity).

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