基本属性 生物活性靶点体外研究体内研究 用途与合成方法 布喹那 价格(试剂级) 供应商 供应信息 相关产品
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布喹那

布喹那

中文名称:布喹那
英文名称:Brequinar
CAS号:96187-53-0
分子式:C23H15F2NO2
分子量:375.37
EINECS号:
Mol文件:96187-53-0.mol
布喹那 结构式

布喹那 性质

熔点 355-357℃ (N,N-dimethylformamide water )
储存条件 2-8°C
溶解度 DMSO:25.9(最大浓度 mg/mL);70.0(最大浓度 mM)
形态 粉末晶体
酸度系数(pKa) pKa 4.45(H2O t=RT I=0.10) (Uncertain)
颜色 白色至浅黄色至浅橙色
CAS 数据库 96187-53-0

布喹那 用途与合成方法

Brequinar (NSC 368390, DuP-785)是二氢乳清酸脱氢酶DHODH抑制剂,在体外IC50约为20 nM。
TargetValue
DHODH
()
20 nM

Brequinar reduces virus progeny production by >90%, with EC 50 of 17 nM. Brequinar (5 μM) also inhibits other orthopoxviruses, and blocks virus DNA replication. Brequinar does not affect virus early gene expression, but has a severe effect on the late stage of the virus cycle. Brequinar reduces the level of envelope protein production and the viral titer in a dose-dependent manner, with EC 50 of 78 nM in the CFI assay. Brequinar (5 μM) inhibits viral RNA synthesis. Brequinar has antiviral effect, but the effect is reversed by pyrimidine. Brequinar-resistant viruses can be selected in cell culture. Brequinar (5 μM) suppresses the luciferase activities from both the WT and NS5 mutant replicons. Brequinar sodium effectively prevents the increase in PyNTP levels with an IC 50 of 0.26 μM. Brequinar sodium effectively inhibits cell proliferation with an IC 50 of 0.26 μM. Brequinar sodium inhibits autophosphorylation of p56 lck with IC 50 of 70 μM; inhibition is 39, 41, and 60% for 25, 50, and 100 μM Brequinar sodium, respectively. Brequinar sodium also inhibits the phosphorylation by p56 lck of the exogenous substrate, histone 2B, with an IC 50 of 70 μM; inhibition is 10, 43, 59, and 86% for 25, 50, 100, and 200 μM Brequinar sodium, respectively. Brequinar sodium inhibits autophosphorylation of p59 fyn with an IC 50 of 105 μM; inhibition is 0, 17, 48, and 65% for 25, 50, 100, and 200 μM Brequinar sodium, respectively. Brequinar sodium also inhibits the phosphorylation by p59 fyn of histone 2B with an IC 50 of 20 μM; inhibition is 26, 54, 79, 83, and 84% for 10, 25, 50, 100, and 200 μM Brequinar sodium, respectively.

Brequinar sodium-treated (10-20 mg/kg/day) mice has a 31% reduction in percentage of packed cell volume compared with untreated BALB/c mice. Brequinar sodium reduces UTP and CTP levels in bone marrow cells by 30 and 25%, respectively. Brequinar sodium (10-20 mg/kg/day) in combination with uridine (1000-2000 mg/kg/day) prevents anemia, and the hematocrits remain at levels (61-63%) comparable with those of untreated controls.

安全信息

海关编码2933.49.7000

布喹那 价格(试剂级)

更新日期 产品编号 产品名称 CAS号 包装 价格
2024-01-25 HY-108325 布喹那 96187-53-0 5mg 700
2024-01-25 HY-108325 布喹那 96187-53-0 10mM * 1mLin DMSO 770

布喹那供应商 更多

上海楼岚生物科技有限公司
现货
联系电话:021-52996696,15000506266 15000506266
产品介绍:
英文名称:Brequinar
CAS:96187-53-0
纯度:98% HPLC
包装信息:5MG;10MG;50MG;100MG,1G,5G
库存量:2g
现货日期:2024/3/20 11:53:58
上海芮晖化工科技有限公司
现货
联系电话:21-31433387 15618786686
产品介绍:
英文名称:Brequinar
CAS:96187-53-0
纯度:97%+
包装信息:0.1G,1G,5G,10G
备注:现货,仅供科研
库存量:>150mg
现货日期:2024/3/27 11:26:07
常州辰鸿生物科技有限公司
现货
联系电话:0519-85788828 13775037613
产品介绍:
英文名称:Brequinar
CAS:96187-53-0
纯度:99%
包装信息:50mg;100mg;250mg;500mg;1g;5g
库存量:>10g
现货日期:2024/3/25 14:06:06
湖北科乐精细化工有限公司
现货
联系电话:027-59101668 19945030958
产品介绍:
中文名称:布喹那
英文名称:Brequinar
CAS:96187-53-0
纯度:98% HPLC
包装信息:5KG;1KG;100g;1g
库存量:1g
现货日期:2024/3/15 10:38:26
江苏弘和药物研发有限公司
联系电话:5108538618
产品介绍:
英文名称:6-fluoro-2-(2'-fluorobiphenyl-4-yl)-3-methylquinoline-4-carboxylic acid
CAS:96187-53-0
纯度:>=95%
备注:CFP1052

最新发布供应信息

布喹那
陕西西化化学工业有限公司 2024-03-06
Brequinar
南京百鑫德诺生物科技有限公司 2024-03-05

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