阿雷地平
阿雷地平 性质
| 熔点 | 155° |
|---|---|
| 沸点 | 530.0±50.0 °C(Predicted) |
| 密度 | 1.284±0.06 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | 二甲基亚砜：125 mg/mL（321.86 mM） |
| 酸度系数(pKa) | 2.56±0.70(Predicted) |
阿雷地平 用途与合成方法
Ca 2+ Channel
Aranidipine (MPC-1304) is a new Ca 2+ channel antagonist in spontaneously hypertensive rats. Following oral administration of Aranidipine at doses of 3 and 10 mg/kg to spontaneously hypertensive rats (SHR), there are significant decreases in B max values for specific [ 3 H](+)-PN 200-110 binding to myocardial membranes compared to the control values. The B max values at 1 h (3 mg/kg), 1 and 6 h (10 mg/kg) are significantly decreased (47.7, 48.9 and 25.8%, respectively) compared to the control values. The effect is greatest at 1 h and decreases with time. The B max values at 6 h (3 mg/kg) and 12 or 24 h (10 mg/kg) after the oral administration of Aranidipine are not significantly different from the control values, suggesting the disappearance of the effect of Aranidipine. The K d values for myocardial [ 3 H](+)-PN 200-110 binding are unaltered by oral administration of Aranidipine.
安全信息
| 毒性 | LD50 in male, female mice, rats (mg/kg): 143, 193, 1982, 1459 orally; LD50 in male, female mice (mg/kg): 7.3, 9.1 i.p. (Nakano) |
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阿雷地平 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-01-25 | HY-U00212 | 阿雷地平 | 86780-90-7 | 5mg | 600 |
| 2024-01-25 | HY-U00212 | 阿雷地平 | 86780-90-7 | 10mg | 900 |
