一叶秋碱
一叶秋碱 性质
| 熔点 | 140-1420C |
|---|---|
| 比旋光度 | D20 -1042° (c = 1 in alc) |
| 沸点 | 357.82°C (rough estimate) |
| 密度 | 1.30±0.1 g/cm3 (20 ºC 760 Torr) |
| 折射率 | 1.5300 (estimate) |
| 储存条件 | Sealed in dry,2-8°C |
| 溶解度 | 二甲基亚砜：≥25mg/mL |
| 形态 | 粉末 |
| 酸度系数(pKa) | 8.29±0.20(Predicted) |
| 颜色 | 粘黄色 |
| 旋光性 (optical activity) | [α]/D -980 to -1015 (C=1, MeOH) |
一叶秋碱 用途与合成方法
| Target | Value |
|
GABA receptor
() |
(-)-Securinine is a major plant-derived alkaloid and also a GABA A receptor antagonist. (-)-Securinine is significantly potent on HeLa cells growth inhibition with IC 50 values of 7.02±0.52 μg/mL (32.3 μM). (-)-Securinine induces apoptosis in a dose-dependent manner in the tested cells, increases the percentage of ROS positive cells and depolarized cells as well as stimulates the activity of ERK1/2, caspase-9 and -3/7. (-)-Securinine also induces cell cycle arrest in S phase. Real-time PCR analysis shows high expression of tumor necrosis factor receptor superfamily (TNFRSF) genes in the cells stimulated with (-)-Securinine.
In this tumor model, tumor growth is significantly impaired with (-)-Securinine treatment indicating that (-)-Securinine has potential as an Acute Myeloid Leukemia (AML) therapeutic. (-)-Securinine treated mice (n=5 mice, bilateral tumors), exhibit an average of more than 75% smaller tumors than vehicle treated mice at the end of the study period.
一叶秋碱 化学药品说明书
一叶秋碱 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-01-25 | HY-N2079 | 1 mg | 228 | ||
| 2024-01-25 | HY-N2079 | 一叶秋碱 | 5610-40-2 | 5mg | 950 |
