129-46-4
基本信息
苏拉明钠
舒拉明钠
苏拉明
蘇拉明鈉
8,8'-[CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]]BIS-1,3,5-NAPHTHALENETRISULFONIC ACID HEXASODIUM SALT
8,8'-CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]BIS-1,3,5-NAPHTHALENETRISULFONIC ACID HEXASODIUM
8,8'-carbonylbisimino-3,1-phenylenecarbonylimino-(4-methyl-3,1-phenylene)carbonyliminobis-1,3,5-naphthalenetrisulfonic acid hexasodium
SURAMINE SODIUM SALT
SURAMIN HEXASODIUM SALT
SURAMIN SODIUM
SURAMIN SODIUM SALT
1-(3-benzamido-4-methylbenzamido)naphthalene-4,6,8-trisulfonicacidsym-3’’-u
1,3,5-naphthylenetrisulfonicacid,8,8’-(ureylenebis(m-phenylenecarbonylimino(4
309f
antrypol
bay205
bayer205
fourneau309
germanin
moranyl
naganin
naganine
naphuridesodium
物理化学性质
| 熔点 | >260°C (dec.) |
| 储存条件 | 0-6°C |
| 溶解度 | H2O: >10mg/mL |
| 形态 | 结晶粉末 |
| 颜色 | 白色 |
| PH值 | pH(10g/l, 25℃) : 5.0～8.0 |
| 水溶解性 | 可溶 |
| 水溶解性 | 可溶于水 |
| BRN | 3694087 |
| 稳定性 | 吸湿性 |
安全数据
| 危险性符号(GHS) |  GHS07 |
| 警示词 | 警告 |
| 危险性描述 | H317 |
| 防范说明 | P261-P272-P280-P302+P352-P333+P313-P321-P363-P501 |
| 安全说明 | 22-24/25 |
| WGK Germany | 3 |
| RTECS号 | QM7000000 |
| F | 3-10 |
| 海关编码 | 29242998 |
| 毒性 | LD50 in mice (mg/kg): ~620 i.v. (Hawking) |
常见问题列表
苏拉明钠是一种可逆的竞争性蛋白酪氨酸磷酸酶 (PTPases) 抑制剂。苏拉明钠是有效的 sirtuins 抑制剂：SirT1 (IC50=297 nM)，SirT2 (IC50=1.15 μM)，SirT5 (IC50=22 μM)。苏拉明钠是竞争性逆转录酶抑制剂 (DNA topoisomerase II: IC50=5 μM)。苏拉明钠有效抑制 IP5K，并且是抗寄生虫 (antiparasitic)，抗肿瘤和抗血管生成剂。
苏拉明钠已经被证实具有抗锥虫病，抗肿瘤，防治眼部增殖性疾病，抗病毒，免疫调节剂的作用，并广泛应用于临床实践中。目前尚未有苏拉明钠具有抗鸡球虫作用的报导，通过苏拉明钠已知的性质无法推断其是否具有抗鸡球虫的作用。
苏拉明钠盐，是一种丙型肝炎病毒 NS3 解旋酶抑制剂。 也用于治疗因胶原蛋白问题引起的关节炎。
|
SIRT1 297 nM (IC 50 ) |
SIRT2 1.15 μM (IC 50 ) |
SIRT5 22 μM (IC 50 ) |
Suramin sodium salt (Suramin hexasodium salt; 50-600 μg/mL; for 24-96 hours) inhibits cells proliferation in a dose-dependent and time-dependent manner and decreases viability in cancer cells.
Suramin sodium salt (300 μg/mL; for 48 hours) induces cells apoptosis and down-regulates mRNA expression in HeLa cells.
Suramin sodium salt (1 mg/mL; 1 hour) significantly suppresses the phosphorylated ERK1/2.
The IC
50
values of HO-8910 PM and HeLa are 319 μg/mL, 476 μg/mL, respectively.
Suramin blocks viral replication in Vero E6 cells.
Cell Proliferation Assay
| Cell Line: | HO-8910 PM ovarian and Hela cervical cancer cells |
| Concentration: | 50, 100, 200, 300, 400, 500 and 600 μg/mL |
| Incubation Time: | For 24, 48, 72 and 96 hours |
| Result: | Inhibited cells proliferation in a dose-dependent and time-dependent manner. |
Apoptosis Analysis
| Cell Line: | HeLa cells |
| Concentration: | 300 μg/mL |
| Incubation Time: | For 48 hours |
| Result: | Induced cells apoptosis. |
Western Blot Analysis
| Cell Line: | PA-SMCs cells |
| Concentration: | 1 mg/mL |
| Incubation Time: | For 1 hour |
| Result: | Significantly suppressed the phosphorylated ERK1/2. |
Suramin sodium salt (Suramin hexasodium salt; 10 mg/kg; IV; twice weekly for 3 weeks) reverses established pulmonary hypertension (PH), thereby normalizing the pulmonary artery pressure values and vessel structure.
| Animal Model: | Adult male Wistar rats (200-225 g) |
| Dosage: | 10 mg/kg |
| Administration: | IV; twice weekly for 3 weeks |
| Result: | Reversed established PH, thereby normalizing the pulmonary artery pressure values and vessel structure. |
苏拉明钠价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | C32854 | 苏拉明钠 Suramin hexasodium salt, 98% | 129-46-4 | 50mg | 2250元 |
| 2024/04/30 | HY-B0879A | 苏拉明钠 Suramin sodium salt | 129-46-4 | 25mg | 2100元 |
| 2024/04/30 | HY-B0879A | 苏拉明钠 Suramin sodium salt | 129-46-4 | 10mM * 1mLin DMSO | 2310元 |