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PHYSOSTIGMINE SALICYLATE

Product Name:
PHYSOSTIGMINE SALICYLATE
CAS No.
57-64-7
Chemical Name:
PHYSOSTIGMINE SALICYLATE
CBNumber:
CB2146890
Molecular Formula:
C22H27N3O5
Formula Weight:
413.47
MOL File:
57-64-7.mol
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PHYSOSTIGMINE SALICYLATE Property

Melting point:
181-183 °C
form 
neat
pka
pKa 1.96/8.08(H2O,t =15) (Uncertain)
Merck 
7384
BRN 
3900576
CAS DataBase Reference
57-64-7(CAS DataBase Reference)
EPA Substance Registry System
Physostigmine salicylate (57-64-7)
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Safety

Hazard Codes 
T+
Risk Statements 
26/28
Safety Statements 
25-45
RIDADR 
UN 1544 6.1/PG 1
WGK Germany 
3
RTECS 
TJ2450000
HazardClass 
6.1(a)
PackingGroup 
II
HS Code 
2939800000
Toxicity
LD50 i.p. in mice: 0.64 mg/kg (Sofia, Knabloch)
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N-Bromosuccinimide Price More Price(2)

Sigma-Aldrich Gold
Product number:
P1600000
Product name :
Physostigmine salicylate
Purity:
European Pharmacopoeia (EP) Reference Standard
Packaging:
p1600000
Price:
$183
Updated:
2019/12/02
Buy:
Buy
Sigma-Aldrich Gold
Product number:
1537003
Product name :
Physostigmine salicylate
Purity:
United States Pharmacopeia (USP) Reference Standard
Packaging:
200mg
Price:
$352.8
Updated:
2019/12/02
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PHYSOSTIGMINE SALICYLATE Chemical Properties,Usage,Production

Chemical Properties

solid

Uses

Physostigmine salicylate (Eserine salicylate) is used as bulk pharmaceuticals (parasympathomimetic, cholinergic, ophthalmic, anti-Alzheimer). Product Data Sheet

Uses

cholinergic, anticholinesterase, miotic

brand name

Antilirium (Forest); Isopto Eserine (Alcon).

General Description

The salicylate ofphysostigmine (eserine salicylate) may be prepared byneutralizing an ethereal solution of the alkaloid with anethereal solution of salicylic acid. Excess salicylic acid isremoved from the precipitated product by washing itwith ether. The salicylate is less deliquescent than thesulfate.
Physostigmine salicylate occurs as a white, shining,odorless crystal or white powder that is soluble in water(1:75), alcohol (1:16), or chloroform (1:6) but much lesssoluble in ether (1:250). On prolonged exposure to air andlight, the crystals turn red. The red may be removed bywashing the crystals with alcohol, although this causes lossof the compound as well. Aqueous solutions are neutral orslightly acidic and take on a red coloration after a period.The coloration may be taken as an index of the loss of activityof physostigmine solutions.

General Description

Crystal form that turns red on exposure to heat or light.

Reactivity Profile

Behaves as a weak acid in solution.

Health Hazard

PHYSOSTIGMINE SALICYLATE is similar to physostigmine. It is classified as super toxic. The probable oral lethal dose (humans) is less than 5 mg/kg or a taste for a 150 lb. person. It is a cholinesterase inhibitor.

Fire Hazard

When heated to decomposition, PHYSOSTIGMINE SALICYLATE emits toxic fumes of nitrogen oxides.

Safety Profile

Poison by ingestion, subcutaneous, intramuscular, intravenous, and intraperitoneal routes. Human systemic effects: arrhythmias, nausea or vomiting. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx See also PHYSOSTIGMINE.

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PHYSOSTIGMINE SALICYLATE Suppliers

Global(47)Suppliers
Meryer (Shanghai) Chemical Technology Co., Ltd.
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57-64-7, PHYSOSTIGMINE SALICYLATERelated Search:

Salicylic acid Piretanide PIRETANIDE IMPURITY A 2-(3-methoxyphenyl)-2-methylpropan-1-amine METOLCARB 1H-Indol-2-amine 3-(3-METHOXYPHENYL)PYRROLIDINE AMINOCARB 2,3-DIHYDROINDOL-5-OL 5-Methoxy-2,3-dihydroindoline PHYSOSTIGMINE PHYSOSTIGMINE SALICYLATE
  • physostigmine,[salicylate(1:1)]
  • physostigmine,salicylate(1:1)
  • physostolsalicylate
  • salicylicacid,compd.withphysostigmine(1:1)
  • tl-1380
  • trimethylpyrrolo[2,3-b]indol-5-ylmethylcarbamate(1:1)
  • Physostigmine Salicylate (200 mg)
  • Physostigmine-d3 salicylate
  • (3aS,8aR)-1,3a,8-triMethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl MethylcarbaMate 2-hydroxybenzoate
  • Eserine salicylate salt >=97.0% (N)
  • PHYSOSTIGMINE SALICYLATE
  • PHYSOSTIGMINE SALICYLATE SALT
  • 2-hydroxy-,compd.with(3as-cis)-1,2,3,3a,8,8a-hexahydro-1,3a,8-benzoicaci
  • ar-44
  • ESERINE MONOSALICYLATE
  • ESERINE SALICYLATE
  • ESERINE SALICYLATE SALT
  • ESERINE SALICYLATE 99.9%
  • Physostigmine monosalicylate
  • Benzoic acid, 2-hydroxy-, compd. with (3aS,8aR)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo2,3-bindol-5-yl methylcarbamate (1:1)
  • PHYSOSTIGMINESALICYLATE,USP
  • ESERINE SALICYLATE(RG)
  • Benzoic acid, 2-hydroxy-, compd. with (3aS,8aR)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-yl methylcarbamate (1:1) (9CI)
  • Benzoic acid, 2-hydroxy-, compd. with (3aS-cis)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-yl methylcarbamate (1:1)
  • Isopto Eserine
  • Physostigmine salicylate (6CI)
  • Physostigmine, monosalicylate (8CI)
  • Pyrrolo[2,3-b]indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, methylcarbamate (ester), (3aS,8aR)-, mono(2-hydroxybenzoate) (salt) (9CI)
  • Pyrrolo[2,3-b]indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, methylcarbamate (ester), (3aS-cis)-, mono(2-hydroxybenzoate) (salt)
  • Salicylic acid, compd. with physostigmine (1:1) (8CI)
  • Physostigminsalicylat
  • Benzoicacid,2-hydroxy-,cpmpd,with(3aS-cis)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indo1-5-ylmethylcarbamateester(1:1)
  • Physostigmine salicylate (Eserine salicylate)
  • 57-64-7
  • C22H27N3O5
  • C15H21N3O2C7H6O3
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