Imipenem-Cilastatin sodium hydrate
- Product NameImipenem-Cilastatin sodium hydrate
- CAS92309-29-0
- CBNumberCB31261281
- MFC28H43N5O9S2
- MW657.8
- EINECS1592732-453-0
- MOL File92309-29-0.mol
Imipenem-Cilastatin sodium hydrate Chemical Properties,Usage,Production
Clinical Use
Antibacterial agentDrug interactions
Potentially hazardous interactions with other drugsAntiepileptics: reduced valproate concentration - avoid.
Antivirals: convulsions reported with concomitant administration of ganciclovir and valganciclovir.
Ciclosporin: variable reports of increase / no change in ciclosporin levels, and of neurotoxicity.
Metabolism
When administered alone, imipenem is metabolised in the kidneys by dehydropeptidase-I, an enzyme in the brush border of the renal tubules, to inactive, nephrotoxic metabolites, with only about 5 to 40 or 45% of a dose excreted in the urine as unchanged active drug. Cilastin inhibits the metabolism of imipenem. When given with cilastatin about 70% of an intravenous dose of imipenem is recovered unchanged in the urine within 10 hours. Cilastatin is also excreted mainly in the urine, the majority as unchanged drug and about 12% as N-acetyl cilastatin. Less than 1% of imipenem is excreted via the bile in the faeces.Preparation Products And Raw materials
Imipenem-Cilastatin sodium hydrate Supplier
Global(57)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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+86-371-66670886 | info@dakenam.com | China | 15932 | 58 | |
+86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 | |
+86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 | |
+86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39916 | 58 | |
+8618523575427 | sales@conier.com | China | 49390 | 58 | |
18503026267 | info@antaichem.com | CHINA | 9641 | 58 | |
+86-029-89586680 +86-18192503167 |
1026@dideu.com | China | 9231 | 58 | |
+86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 29016 | 58 | |
0571-85134551 | info@afinechem.com | CHINA | 15377 | 58 | |
+86-27-59207850 +86-13986145403 |
info@fortunachem.com | China | 5989 | 58 |
View Lastest Price from Imipenem-Cilastatin sodium hydrate manufacturers
$0.00/ KG/Tin
Imipenem≥400μg/mg,Cilastatin(C16H26N2O5S) ≥400μg/mg;USP
WUHAN FORTUNA CHEMICAL CO., LTD
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