ChemicalBook > CAS DataBase List > Levothyroxine sodium

Levothyroxine sodium

Product Name:
Levothyroxine sodium
CAS No.
55-03-8
Chemical Name:
Levothyroxine sodium
CBNumber:
CB4106276
Molecular Formula:
C15H20I4NNaO9
Formula Weight:
888.93
MOL File:
55-03-8.mol
More
Less

Levothyroxine sodium Property

Melting point:
207-210 (dec.)(lit.)
alpha 
D20 -4.4° (c = 3 in 70% ethanol)
Density 
d420 2.381
storage temp. 
2-8°C
solubility 
cell culture medium: 0.1 mg/mL
form 
powder
InChIKey
JMHCCAYJTTWMCX-QWPJCUCISA-M
EPA Substance Registry System
Levothyroxine sodium (55-03-8)
More
Less

Safety

Safety Statements 
22-24/25
RIDADR 
2811
WGK Germany 
3
RTECS 
YP2833760
3-8-10
HazardClass 
6.1(a)
PackingGroup 
II
HS Code 
2937909000
More
Less

N-Bromosuccinimide Price More Price(2)

TCI Chemical Gold
Product number:
T0245
Product name :
L-Thyroxine Sodium Salt Pentahydrate
Purity:
>98.0%(T)
Packaging:
1g
Price:
$40
Updated:
2020/06/24
Buy:
Buy
TCI Chemical Gold
Product number:
T0245
Product name :
L-Thyroxine Sodium Salt Pentahydrate
Purity:
>98.0%(T)
Packaging:
100mg
Price:
$14
Updated:
2020/06/24
Buy:
Buy
More
Less

Levothyroxine sodium Chemical Properties,Usage,Production

Chemical Properties

Levothyroxine sodium  is White Solid

Uses

One of the thyroid hormones involved in the maintenance of metabolic homeostasis. Synthesized and stored as amino acid residues of thyroglobulin, the major protein component of the thyroid follicular colloid. Synthesis and secretion are regulated by the pituitary hormone (TSH). Deiodinated in peripheral tissues to the active metabolite, liothyronine. The D-form has very little activity as a thyroid hormone, but has been used to treat hyperlipidemia.

Definition

ChEBI: The sodium salt of L-thyoxine. It is used as replacement therapy in the treatment of hypothyroidism.

Indications

Levothyroxine sodium (Levothroid, Synthroid, Levoxine) is the sodium salt of the naturally occurring levorotatory isomer of T4. It is the preparation of choice for maintenance of plasma T4 and T3 concentrations for thyroid hormone replacement therapy in hypothyroid patients. It is absorbed intact from the gastrointestinal tract, and its long half-life allows for convenient oncedaily administration. Since much of the T4 is deiodinated to T3, it is usually unnecessary to use more expensive preparations containing both T4 and T3.The aim is to establish euthyroidism with measured serum concentrations of T4, T3, and TSH within the normal range.
The TSH-suppressive effects of exogenous T4 also prove useful in removing the stimulatory effects of TSH on the thyroid gland in the management of simple nonendemic goiter, chronic thyroiditis, and TSHdependent thyroid carcinoma.

brand name

Levo-T (Alara); Levolet (Vintage); Levothroid (Lloyd); Levoxyl (Jones); Novothyrox (Genpharm); Synthroid (Abbott); Unithroid (Stevens J).

General Description

Levothyroxine sodium,O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-2-tyrosinemonosodium salt, hydrate (Synthroid, Letter, Levoxine,Levoid), is the sodium salt of the levo isomer of thyroxine,which is an active physiological principle obtained from thethyroid gland of domesticated animals used for food by humans.It is also prepared synthetically. The salt is a light yellow,tasteless, odorless powder. It is hygroscopic but stablein dry air at room temperature. It is soluble in alkali hydroxides,1:275 in alcohol, and 1:500 in water, to give a pH ofabout 8.9.

Clinical Use

Liothyronine sodium occurs in vivo together withlevothyroxine sodium; it has the same qualitative activitiesas thyroxine but is more active. It is absorbed readily fromthe gastrointestinal tract, is cleared rapidly from the bloodstream,and is bound more loosely to plasma proteins than isthyroxine, probably because of the less acidic phenolic hydroxylgroup.Its uses are the same as those of levothyroxine sodium,including treatment of metabolic insufficiency, male infertility,and certain gynecological disorders.

Veterinary Drugs and Treatments

Levothyroxine sodium is indicated for the treatment of hypothyroidism in all species.

Levothyroxine sodium Preparation Products And Raw materials Raw materials

Raw materials

Preparation Products

Less

Levothyroxine sodium Suppliers

Global(131)Suppliers
Shifang ShengYuan Technology Co., Ltd.
Tel:
13402890778,
Fax:
qq:1120021438
Email:
1120021438@qq.com
Country:
China
ProdList:
174
Advantage:
56
Suzhou Pharmaceutical Technology co.,ltd
Fax:
051282177481
Email:
lsenfy@126.com
Country:
China
ProdList:
56
Advantage:
61
Shanghai Mokay Pharmaceutical Technology Co., Ltd.
Tel:
021-60257269 18601606476
Fax:
+86-21-60253672
Email:
yl@mkpharma.cn
Country:
China
ProdList:
206
Advantage:
58
上海默凯医药科技有限公司 Shanghai Mokai Pharmaceutical Technology Co., Ltd.
Tel:
021-60951261- ;021-60951261-
Email:
nancy@mkpharma.cn;dhn@mkpharma.cn
Country:
China
ProdList:
228
Advantage:
58
J & K SCIENTIFIC LTD.
Tel:
010-82848833- ;010-82848833-
Fax:
86-10-82849933
Email:
jkinfo@jkchemical.com;market6@jkchemical.com
Country:
China
ProdList:
96815
Advantage:
76
TCI (Shanghai) Development Co., Ltd.
Tel:
021-67121386 / 800-988-0390
Fax:
021-67121385
Email:
Sales-CN@TCIchemicals.com
Country:
China
ProdList:
24555
Advantage:
81
LGM Pharma
Tel:
1-(800)-881-8210
Fax:
615-250-9817
Email:
inquiries@lgmpharma.com
Country:
United States
ProdList:
1938
Advantage:
70
Nanjing Chemlin Chemical Co., Ltd
Tel:
025-83697070
Fax:
+86-25-83453306
Email:
info@chemlin.com.cn
Country:
China
ProdList:
19991
Advantage:
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel:
021-54306202- ;021-54308259-
Fax:
+86-21-64545202
Email:
info@hanhonggroup.com;info@hanhonggroup.com
Country:
China
ProdList:
43258
Advantage:
64

55-03-8, Levothyroxine sodium Related Search:

Levothyroxine sodium 3 5-DIIODOTHYROPROPIONIC ACID 3-IODO-L-TYROSINE 3,5-Diiodo-L-thyronine O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine DL-LEVOTHYROXINE SODIUM 3,5-DIIODO-DL-THYRONINE 1-METHOXY-3,5-DIIODOBENZENE 3-IODO-L-THYRONINE REVERSE T3 3 5-DIIODO-L-TYROSINE DIHYDRATE 98 3-Iodophenol DL-THYRONINE Sodium bicarbonate Sodium benzoate Inositol DL-THYROXINE L-Tyrosine
  • Levothyroxine sodium
  • Sodium 4-O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine
  • (S)-2-Amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propionic Acid odium
  • (s)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propionic acid sodium salt
  • sodium (s)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propionate
  • L-THYROXINE SODIUM ANHYDROUS
  • Levothyroxine Sdium
  • levothyroxine sodium anhydrous
  • LT4 sodium
  • L-T4 sodium
  • (S)-2-Amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propionic Acid Sodium Salt Sodium (S)-2-Amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propionate
  • sodiuM (S)-2-aMino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)propanoate
  • L-Tyrosine,O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, sodiuM salt (1:1)
  • Levothyroxine sodium ,T4
  • <small>L</small>-Thyroxine Sodium Salt Pentahydrate
  • SODIUM (S)-2-AMINO-3-[4-(4-HYDROXY-3,5-DIIODOPHENOXY)-3,5-DIIODOPHENYL]PROPIONATE PENTAHYDRATE
  • (S)-2-AMINO-3-[4-(4-HYDROXY-3,5-DIIODOPHENOXY)-3,5-DIIODOPHENYL]PROPIONIC ACID SODIUM SALT PENTAHYDRATE
  • 3-[4-(4-HYDROXY-3,5-DIIODOPHENOXY)-3,5-DIIODOPHENYL]-L-ALANINE SODIUM SALT PENTAHYDRATE
  • 3-[4-(4-HYDROXY-3,5-DIIODOPHENOXY)-3,5-DIIODOPHENYL]-L-ALANINE PENTAHYDRATE
  • L-THYROXINE SODIUM SALT PENTAHYDRATE
  • L-THYROXINE SODIUM PENTAHYDRATE
  • 3-Amino-4-(4-(4-OH-3,5-diiodophenoxy)-3,5-diiodophenyl))but.ac.Na salt
  • L-ThyroxineSodiumSaltB.P.
  • 55-03-8
  • 55-03-86106-07-6
  • C15H11I4NNaO4
  • C15H10I4NNaO45H2O
  • C15H10I4NO4Na
  • Other Protein/Peptide Hormones
  • Hormones
  • Thyroxine (T4)
  • Cytokines, Growth Factors and Hormones
  • Cell Signaling and Neuroscience
  • Cell Biology
  • BioChemical
  • Medicine intermediate
  • Amino Acids
  • Biochemistry
  • Biological-modified Amino Acids
  • Amino Acids & Derivatives
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Steroid and Hormone