Description
Retinyl acetate (retinol acetate, vitamin A acetate,127-47-9) is a natural form of vitamin A. It is the acetate ester of retinol. It consists of yellow crystals which are greasy or sticky. It has a mild, characteristic odor. It has potential antineoplastic and chemo-preventive activities. It can be used to fortify food with vitamin A. As vitamin A acetate can induce cell differentiation and inhibit cell proliferation, it is used in skin-conditioning agent.
Reference
Volker Bühler, Vademecum for Vitamin Formulations, 2001, ISBN 3-8047-1834-5
Chemical Properties
Crystalline
Uses
Retinyl acetate has been used:
- a control diet to study its effect at different developmental periods in fish larvae
- to study its inhibitory effects on Mycobacterium avium?subspecies?paratuberculosis?(MAP) strains
- as an internal standard in high performance liquid chromatography (HPLC) to quantify vitamin A in fortified milk
Uses
Essential micronutrient
Definition
ChEBI: Retinyl acetate is an acetate ester. It is functionally related to an all-trans-retinol.
General Description
Retinyl acetate is suitable for use in the retention identification of the analyte when using HPLC and GC. Not intended for use as an activity reference standard. It has been thoroughly evaluated to ensure the utmost quality. Neat, unless otherwise noted. Certificate of Composition provided with the purchase.
Flammability and Explosibility
Not classified
Biochem/physiol Actions
Retinyl esters provide pools of vitamin A that are converted into retinol and other retinoids as required. Retinyl acetate is used in a wide range of biological applications. It acts as a chemopreventive agent. Retinyl acetate also has antineoplastic property.
Safety Profile
Moderately toxic by
ingestion. Experimental teratogenic and
reproductive effects. Questionable
carcinogen with experimental neoplastigenic
data. Mutation data reported. When heated
to decomposition it emits acrid smoke and
irritating fumes. See also VITAMIN A.
Purification Methods
The acetate is separated from retinol by column chromatography, then crystallised from MeOH. [Kofler and Rubin Vitamins and Hormones (NY) 18 315 1960 for purification methods]. Store it in the dark, under N2 or Ar, at 0o. [Beilstein 6 IV 4135.]
