Uses
Promazine is an antipsychotic and a tranquilizer.
Uses
In psychiatric practice, promazine is used in minor cases of psychomotor excitement in
schizophrenics, in paranoid and manic-depressive conditions, for neurosis, alcoholic
psychosis, and others. It is sometimes used in anesthesiological practice.
Definition
ChEBI: A phenothiazine deriative in which the phenothiazine tricycle has a 3-(dimethylaminopropyl) group at the N-10 position.
brand name
Sparine (Baxter Healthcare); Sparine (Wyeth).
General Description
Promazine, 10-[3-(dimethylamino) propyl-(phenothiazine monohydrochloride (Sparine), was introducedinto antipsychotic therapy after its 2-chloro-substitutedrelative. The 2H-substituent vis-à-vis the 2Clsubstituent gives a milligram potency decrease as an antipsychotic,as encompassed in Gordon’s rule. Tendency toEPS is also lessened, which may be significant, especially ifit is decreased less than antipsychotic potency.
Synthesis
Promazine, 10-(3-dimethylaminopropyl)phenothiazine (6.1.1), is prepared
by the alkylation of phenothiazine with 3-dimethylaminopropylchloride in the presence of
sodium amide [1¨C3].
