Description
Picotamide is an unique antithrombotic agent which acts by selectively inhibiting
thromboxane synthesis and blocking platelet thromboxane receptors without affecting
prostaglandin synthesis. It is reported to be useful in the treatment of myocardial
infarction, cerebrovascular disorders, pulmonary embolism and atherosclerosis.
Originator
Manetti-Roberts (Beecham (Italy)
Uses
Picotamide is a dual inhibitor of thromboxane A2 and thromboxane A2 synthase. It is used in aptamers for targeting coagulation factor XIII and there used for treatment of thrombosis.
Definition
ChEBI: 4-methoxy-N1,N3-bis(3-pyridinylmethyl)benzene-1,3-dicarboxamide is a member of benzamides.
References
Modesti, et al. (1989), Competitive inhibition of platelet thromboxane A2 receptor binding by picotamide; Eur. J. Pharmacol.. 169 85
Modesti, et al. (1991), Acute reduction of TxA2 platelet binding sites after in vivo administration of a TxA2 inhibitor; Br. J. Pharmacol.. 31 439
Ratti et al. (1998), Picotamide, an antithromboxane agent. Inhibits the migration and proliferation of arterial myocytes; Eur. J. Pharmacol. 355 77
