ChemicalBook CAS DataBase List NAPHTHOL AS-E PHOSPHATE

NAPHTHOL AS-E PHOSPHATE

Product NameNAPHTHOL AS-E PHOSPHATE
CAS18228-17-6
CBNumberCB9737978
MFC17H13ClNO5P
MW377.72
EINECS242-106-1
MDL NumberMFCD00042718
MOL File18228-17-6.mol
MSDS FileSDS

Chemical Properties

Density	1.567±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	DMSO: soluble
form	A crystalline solid
pka	1.04±0.30(Predicted)
BRN	6664478
FDA UNII	H6R6B93QFC

Safety

WGK Germany	3
F	8-10-21

NAPHTHOL AS-E PHOSPHATE Price

Product number	Packaging	Price	Product description	Buy
Sigma-Aldrich 70485	250mg	$105	Naphthol AS-E phosphate for histology	Buy
TRC N368028	100mg	$60	Naphthol AS-E phosphate	Buy
ChemScene CS-0027313	10mg	$70	KG-501 98.08%	Buy
Biosynth Carbosynth EN69791	500mg	$75	Naphthol AS-E phosphate - 60%	Buy
Biosynth Carbosynth EN69791	250mg	$45	Naphthol AS-E phosphate - 60%	Buy

NAPHTHOL AS-E PHOSPHATE Chemical Properties,Usage,Production

Biological Activity

Naphthol AS-E phosphate is a CREB inhibitor that disrupts CREB-dependent transcription (Ki=10 μM) and CREB:CBP interaction (Ki=50 μM). It also disrupts the binding of phosphorylated CREB (Ser-133) to KIX with a Ki of approximately 90 μM.

in vitro

Naphthol AS-E phosphate inhibited (or partially inhibited) the induction of cAMP-related genes by preventing CREB:CBP interaction. KG-501 inhibited neurite outgrowth, synaptogenesis and reduced MAP2+ neurons.

in vivo

Naphthol AS-E phosphate inhibited the expression of CREB, CCL2 and ERK phosphorylation, while significantly reducing cAMP levels. CREB may help to fight neuroinflammation through the cAMP/ERKadjustment pathway, thereby protecting nerves.It significantly promoted neurological function in a mouse model treated with azomethane oxide (AOM), reducing ERK phosphorylation levels and cAMP concentrations in the cortex.

target

Preparation Products And Raw materials

NAPHTHOL AS-E PHOSPHATE Supplier

Target	Value
CREB ()

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	967	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58

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