Acesulfame potassium suppliers

Acesulfame potassium

CAS:: 55589-62-3

MF:: C4H4KNO4S

MW:: 201.24

SecurityInformation

Symbol(GHS) ：: GHS07

Signal word ：: Warning

Hazard statements ：: H315-H319

Precautionary statements ：: P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Risk Statements ：: 36/37/38

Safety Statements ：: 26-36/37/39

WGK Germany ：: 1

RTECS ：: RP4489165

HS Code ：: 2934990002

Toxicity：: LD50 in rats (mg/kg): 7431 orally, 2243 i.p. (Mayer, Kemper)

Use：: Acesulfame potassium occurs as a colorless to white-colored, odorless, crystalline powder with an intensely sweet taste.Acesulfame potassium is synthesized from acetoacetic acid tertbutyl ester and fluorosulfonyl isocyanate. The resulting compound is transformed to fluorosulfonyl acetoacetic acid amide, which is then cyclized in the presence of potassium hydroxide to form the oxathiazinone dioxide ring system. Because of the strong acidity of this compound, the potassium salt is produced directly. An alternative synthesis route for acesulfame potassium starts with the reaction between diketene and amidosulfonic acid. In the presence of dehydrating agents, and after neutralization with potassium hydroxide, acesulfame potassium is formed.Acesulfame potassium is used as an intense sweetening agent in cosmetics, foods, beverage products, table-top sweeteners, vitamin and pharmaceutical preparations, including powder mixes, tablets, and liquid products. It is widely used as a sugar substitute in compounded formulations,and as a toothpaste sweetener. The approximate sweetening power is 180–200 times that of sucrose, similar to aspartame, about one-third as sweet as sucralose, one-half as sweet as sodium saccharin, and about 4-5 times sweeter than sodium cyclamate.It enhances flavor systems and can be used to mask some unpleasant taste characteristics.Acesulfame potassium is widely used in beverages, cosmetics, foods, and pharmaceutical formulations, and is generally regarded as a relatively nontoxic and nonirritant material. Pharmacokinetic studies have shown that acesulfame potassium is not metabolized and is rapidly excreted unchanged in the urine. Long-term feeding studies in rats and dogs showed no evidence to suggest acesulfame potassium is mutagenic or carcinogenic. The WHO has set an acceptable daily intake for acesulfame potassium of up to 15 mg/kg body-weight.The Scientific Committee for Foods of the European Union has set a daily intake value of up to 9 mg/kg of body-weight. LD50 (rat, IP): 2.2 g/kg LD50 (rat, oral): 6.9–8.0 g/kgAcesulfame potassium possesses good stability. In the bulk form it shows no sign of decomposition at ambient temperature over many years. In aqueous solutions (pH 3.0–3.5 at 208℃) no reduction in sweetness was observed over a period of approximately 2 years. Stability at elevated temperatures is good, although some decomposition was noted following storage at 408℃ for several months. Sterilization and pasteurization do not affect the taste of acesulfame potassium. The bulk material should be stored in a well-closed container in a cool, dry place and protected from light.

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Shaanxi TNJONE Pharmaceutical Co., Ltd