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ChemicalBook >> CAS DataBase List >>Papaverine hydrochloride

Papaverine hydrochloride suppliers

Papaverine hydrochloride

CAS:: 61-25-6

MF:: C20H22ClNO4

MW:: 375.85

SecurityInformation

Symbol(GHS) ：: GHS06

Signal word ：: Danger

Hazard statements ：: H301

Precautionary statements ：: P264-P270-P301+P310-P405-P501

Hazard Codes ：: Xn,C,F

Risk Statements ：: 22-34-11

Safety Statements ：: 22-45-36/37/39-26-16

RIDADR ：: UN 1544 6.1/PG 3

WGK Germany ：: 1

RTECS ：: NW8575000

F ：: 8

TSCA ：: Yes

HazardClass ：: 6.1

PackingGroup ：: III

HS Code ：: 29391900

Toxicity：: LD50 in mice, rats (mg/kg): 27.5, 20 i.v.; 150, 370 s.c. (Levis)

Use：: Papaverine hydrochloride,6,7-dimethoxy-1-veratrylisoquinoline hydrochloride,was isolated by Merck in 1848 from opium,in which it occurs to the extent of about 1%. Althoughits natural origin is closely related to morphine, the pharmacologicalactions of papaverine hydrochloride areunlike those of morphine. Its main effect is as a spasmolyticon smooth muscle, acting as a direct, nonspecificrelaxant on vascular, cardiac, and other smooth muscle.Because of its broad antispasmodic action on ACh muscarinicreceptors, it is often called a nonspecific antagonist.Papaverine hydrochloride has been used in the treatmentof peripheral vascular disorders, but its use is limitedby lack of potency. Papaverine hydrochloride interferes with the mechanismof muscle contraction by inhibiting the cyclic nucleotidephosphodiesterases in smooth muscle cells responsible forconverting cAMP and cyclic guanosine monophosphate(cGMP) to 5' -AMP and 5' -GMP, respectively. The increasedlevels of cAMP and cGMP are associated with muscle relaxation through their phosphorylation of myosinlight-chain kinase.PAPAVERINE HYDROCHLORIDE is Crystalline Solid Papaverine hydrochloride,6,7-dimethoxy-1-veratrylisoquinoline hydrochloride,was isolated by Merck in 1848 from opium,in which it occurs to the extent of about 1%. Althoughits natural origin is closely related to morphine, the pharmacologicalactions of papaverine hydrochloride areunlike those of morphine. Its main effect is as a spasmolyticon smooth muscle, acting as a direct, nonspecificrelaxant on vascular, cardiac, and other smooth muscle.Because of its broad antispasmodic action on ACh muscarinicreceptors, it is often called a nonspecific antagonist.Papaverine hydrochloride has been used in the treatmentof peripheral vascular disorders, but its use is limitedby lack of potency. Papaverine hydrochloride interferes with the mechanismof muscle contraction by inhibiting the cyclic nucleotidephosphodiesterases in smooth muscle cells responsible forconverting cAMP and cyclic guanosine monophosphate(cGMP) to 5' -AMP and 5' -GMP, respectively. The increasedlevels of cAMP and cGMP are associated with muscle relaxation through their phosphorylation of myosinlight-chain kinase.

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You can find Papaverine hydrochloride suppliers, manufacturers, and distributors from countries such as China, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.

Wuhan Topule Biopharmaceutical Co., Ltd

Papaverine hydrochloride
Remarks: Purity: 0.98 | Package: 100mg;1g;500g | CustNote: Topule Company operates with integrity and has its own laboratory, which supports packaging and customization. Payment will be made after the product has passed third-party testing
TEL: 027-87215551
CHINA Trader

CONIER CHEM AND PHARMA LIMITED

papaverine hydrochloride
Remarks: Purity: 99% | Package: 1kg
CHINA Trader

career henan chemical co

Isoquinoline,1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-, hydrochloride (1:1)
Remarks: Purity: >=98% | Package: 1KG;9.8USD
TEL: 0371-+86-0371-86658258
CHINA Trader

￥9.80/1KG

Shaanxi Dideu Medichem Co. Ltd

Papaverine Hydrochloride
Remarks: Purity: 99% | Package: 1KG;1USD
TEL: 0086-+86-029-81138252
CHINA Trader

￥1.00/1KG

Hubei Ipure Biology Co., Ltd

Papaverine Hydrochloride
Remarks: Purity: 99% | Package: 10g;500g;1kg;10kg
CHINA Trader

Shanghai UCHEM Inc.

Papaverine hydrochloride
Remarks: Purity: 0.98 | Package: 25KG;1KG
CHINA Trader

Shaanxi Dideu Medichem Co. Ltd

Papaverine hydrochloride USP/EP/BP
Remarks: Purity: 99.9% | Package: 25kgs/Drum;200kgs/Drum | CustNote: FDA GMP CEP Approved Manufacturer
TEL: 29-+86-029-89586680
CHINA Trader

Dideu Industries Group Limited

Papaverine hydrochloride
Remarks: Purity: 99.9%|Package: 1g;1.1USD
TEL: 029-+86-29-89586680
CHINA Trader

￥1.10/1g

Hebei Duling International Trade Co. LTD

Papaverine hydrochloride
TEL: +86-0311-87836622
CHINA Trader

LEAP CHEM CO., LTD.

Papaverine hydrochloride
Remarks: Package: 1g; 5g; 25g; 1kg; 5kg; 25kg
TEL: 852-30606658
CHINA Trader