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ChemicalBook >> CAS DataBase List >>Ribavirin

Ribavirin suppliers

Ribavirin

CAS:: 36791-04-5

MF:: C8H12N4O5

MW:: 244.21

SecurityInformation

Symbol(GHS) ：: GHS08

Signal word ：: Danger

Hazard statements ：: H341-H360FD

Precautionary statements ：: P201-P308+P313

Hazard Codes ：: T,Xi

Risk Statements ：: 61-36/38

Safety Statements ：: 53-22-45-37/39-26

WGK Germany ：: 3

RTECS ：: XZ4250000

HS Code ：: 29349990

Toxicity：: LD50 i.p. in mice: 1.3 g/kg; orally in rats: 5.3 g/kg (Witkowski, 1972)

Use：: 1, Ribavirin can be subject to phosphorylation in red blood cells to generate ribavirin monophosphate, diphosphate and triphosphate, wherein the ribavirin monophosphate is the strong inhibitor of the inosine monophosphate dehydrogenase which can inhibit cellular guanylate synthesis, decrease the tri-phosphorylation of the intracellular guanylate triphosphate, and blocking the synthesis of viral nucleic acid. 2, ribavirin triphosphate can inhibit the influenza virus RNA polymerase and interfere with viral replication. 3, ribavirin triphosphate can inhibit the synthesis of viral mRNA 5 'end and transcriptase, thereby inhibiting the DNA and RNA synthesis. It has inhibitory effect on various kinds of viruses (including DNA viruses and RNA viruses). It also has prevention and treatment effect on the influenza, adenovirus pneumonia, hepatitis, herpes, and measles and is also effective on treating the epidemic hemorrhagic fever. 4, it is mainly excreted through urine in the prototype with also a small amount of de-sugarized ribavirin metabolites with a small amount discharged from the feces. The above information is edited by the Chemicalbook of Dai Xiongfeng.

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