Mafenide (Sulfamylon) is a synthetic antibacterial agent related chemically, but
not pharmacologically, to the sulfonamides. The drug appears to interfere with
bacterial cellular metabolism and is not antagonized by PABA, pus, or serum. It is
bacteriostatic against many gram-positive and gram-negative organisms, including
staphylococci, streptococci, and Pseudomonas species. Mafenide is highly soluble
and diffuses easily through an eschar. After percutaneous absorption, the drug is
metabolized; it acts as a weak carbonic anhydrase inhibitor and may therefore cause
systemic acidosis.
Mafenide is used primarily in the adjunctive treatment of second- and thirddegree
burn wounds. It may cause severe pain on application, and active allergic
contact sensitivity may develop.
