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Amsacrine

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Amsacrine Basic information

Product Name:
Amsacrine
CAS:
51264-14-3
MF:
C21H19N3O3S
MW:
393.46
EINECS:
257-094-3
Mol File:
51264-14-3.mol
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Amsacrine Chemical Properties

Melting point:
230-240 °C
Boiling point:
563.0±60.0 °C(Predicted)
Density 
1.2205 (rough estimate)
refractive index 
1.6740 (estimate)
pka
8.55±0.10(Predicted)
CAS DataBase Reference
51264-14-3
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Safety Information

RIDADR 
3249
HazardClass 
6.1(b)
PackingGroup 
III
Hazardous Substances Data
51264-14-3(Hazardous Substances Data)
Toxicity
LD50 in male, female CDF1 mice: 810 mg/m2; 729 mg/m2 orally (Pavkov)
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Amsacrine Usage And Synthesis

Description

Amsacrine is a cytostatic reported to be active against adult lymphoblastic leukemia which has failed primary treatment or become resistant. Its clinical use, however, is associated with significant neuro-, gastro- and hepatotoxicity.

Originator

Auckland Cancer Chemotherapy Lab (New Zealand)

Uses

Antineoplastic.

Definition

ChEBI: A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.

brand name

Amsidyl (Parke-Davis);Amsakrin.

Amsacrine Preparation Products And Raw materials

Raw materials

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AmsacrineSupplierMore

Jia Xing Isenchem Co.,Ltd
Tel:
0573-85280080-
Email:
isenchem@163.com;
LGM Pharma
Tel:
1-(800)-881-8210
Email:
inquiries@lgmpharma.com
XiaoGan ShenYuan ChemPharm co,ltd
Tel:
0712-2580635- ;0712-2580635
Email:
1791901229@qq.com;1791901229@qq.com;
BOC Sciences
Tel:
Email:
info@bocsci.com
Shanghai LiuShi Pharmaceutical Technology Co., Ltd.
Tel:
021-60135539
Email:
shlschemical@hotmail.com
Basic information Safety Related Supplier