无中文名称
无中文名称 性质
| 沸点 | 592.9±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.52±0.1 g/cm3(Predicted) |
| 储存条件 | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| 溶解度 | DMF：25mg/mL； DMF:PBS(pH 7.2)(1:1)：0.5 mg/ml； DMSO：10mg/mL；乙醇：1mg/mL |
| 形态 | 结晶固体 |
| 酸度系数(pKa) | 4.01±0.30(Predicted) |
无中文名称 用途与合成方法
| Target | Value |
|
casein kinase 1 epsilon
(Cell-free assay) | 32 nM |
|
casein kinase 1 delta
() | 711 nM |
PF-4800567 is a potent and selective inhibitor of casein kinase 1ϵ (CK1ϵ), with an IC 50 of 32 nM, which is greater than 20-fold selectivity over CK1δ (IC 50 , 711 nM). PF-4800567 shows inhibitory activity against CK1ϵ and CK1δ in whole cells, with IC 50 s of 2.65 and 20.38 μM, respectively. PF-4800567 (0.01-10 μM) blocks CK1ϵ-mediated PER3 nuclear localization mediated by CK1ϵ and suppresses PER2 degradation at 1 μM. In addition, PF-4800567 has little effect on the circadian clock at 32 nM.
PF-4800567 (100 mg/kg, s.c.) is rapidly absorpted and distributed in plasma and brain of mice.
PF 4800567 is a selective casein kinase inhibitor; displays 22-fold greater potency towards CK1ε than CK1δ (IC50 values are 32 and 711 nM for CK1ε and CK1δ respectively). ATP competitive. Displays minimal effect on the circadian clock.
无中文名称 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-04-30 | S2249 | 3-((3-氯苯氧基)甲基)-1-(四氢-2H-吡喃-4-基)-1H-吡唑并[3,4-D]嘧啶-4-胺 | 1188296-52-7 | 5mg | 930.64 |
| 2024-04-30 | S2249 | 3-((3-氯苯氧基)甲基)-1-(四氢-2H-吡喃-4-基)-1H-吡唑并[3,4-D]嘧啶-4-胺 | 1188296-52-7 | 25mg | 3200.88 |
