ChemicalBook >  Product Catalog >  API >  Other Chemical drugs >  Infection Prevention and Control of Epidemic >  1-(1-NAPHTHYL)-2-THIOUREA

1-(1-NAPHTHYL)-2-THIOUREA

Basic information Safety Related Supplier

1-(1-NAPHTHYL)-2-THIOUREA Basic information

Product Name:
1-(1-NAPHTHYL)-2-THIOUREA
CAS:
86-88-4
MF:
C11H10N2S
MW:
202.28
EINECS:
201-706-3
Mol File:
86-88-4.mol
More
Less

1-(1-NAPHTHYL)-2-THIOUREA Chemical Properties

Melting point:
193 °C
Boiling point:
377.6±25.0 °C(Predicted)
Density 
1.333
refractive index 
1.5500 (estimate)
storage temp. 
Poison room
solubility 
4.3 and 86 g/L in acetone and triethylene glycol, respectively (Windholz et al., 1983)
form 
Crystals or Crystalline Powder
pka
13.12±0.70(Predicted)
color 
Grayish to beige-brown
Odor
bitter taste
Water Solubility 
600 mg/L at 20 °C (quoted, Windholz et al., 1983)
Merck 
14,722
BRN 
778118
Exposure limits
NIOSH REL: TWA 0.3 mg/m3, IDLH 100 mg/m3; OSHA PEL: TWA 0.3 mg/m3
CAS DataBase Reference
86-88-4(CAS DataBase Reference)
EPA Substance Registry System
.alpha.-Naphthylthiourea (86-88-4)
More
Less

Safety Information

Hazard Codes 
T+
Risk Statements 
28-40
Safety Statements 
28-36/37-45-25-23
RIDADR 
1651
WGK Germany 
2
RTECS 
YT9275000
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
I
HS Code 
29309090
Toxicity
Acute oral LD50 for Norwegian rats 6–8 mg/kg (Hartley and Kidd, 1987).

MSDS

  • Language:EnglishProvider:ALFA
More
Less

1-(1-NAPHTHYL)-2-THIOUREA Usage And Synthesis

Chemical Properties

greyish to beige-brown crystals or cryst. powder

Chemical Properties

Alpha-naphthylthiourea (α-naphthalene thiourea) is a pure white or beige-brown solid/ blue-gray powder. It is hard to dissolve in water, acid, and general organic solvents, but dissolves in boiling ethanol and alkaline solution. On decomposition, ANTU releases carbon monoxide, toxic and irritating fumes and gases, and carbon dioxide. It is a rodenticide and a poison bait to lure rodents.

Chemical Properties

ANTU is a noncombustible, white crystalline solid or gray powder. Odorless.

Physical properties

Colorless crystals when pure. Technical product is grayish-blue. Odorless solid. Bitter taste.

Uses

Rodenticide

Uses

Rodenticide. Specific control for the adult Norway rat; less toxic to other rat species.

General Description

White crystal or powder; technical product is gray powder. Has no odor but a bitter taste. Used primarily as a rodenticide for control of adult Norway rats. Not produced commercially in the U.S.

Air & Water Reactions

Slightly soluble in water.

Reactivity Profile

1-(1-NAPHTHYL)-2-THIOUREA is incompatible with the following: Strong oxidizers, silver nitrate .

Hazard

Toxic by ingestion

Health Hazard

Moderately toxic: probable oral lethal dose (human) 0.5-5 gm/kg, or between 1 ounce and 1 pint (or l lb.) for 150 lb. person. Chronic sublethal exposure may cause antithyroid activity. Can produce hyperglycemia of three times normal in three hours. People with chronic respiratory disease or liver disease may be especially at risk.

Health Hazard

α-Naphthalene thiourea, a rodenticide, is very toxic and is fatal if swallowed. Exposures to ANTU cause poisoning with symptoms that include, but are not limited to, headache, weakness, dizziness, shortness of breath, cyanosis, blood abnormalities, methemoglobinemia, irritation of the digestive tract, liver and kidney damage, cardiac and CNS disturbances, convulsions, tachycardia, dyspnea, vertigo, tinnitus, weakness, disorientation, lethargy, drowsiness, and fi nally coma and death. The target organs include the blood, kidneys, CNS, liver, lungs, cardiovascular system, and blood-forming organs.

Fire Hazard

Emits sulfur dioxide, oxides of nitrogen, and carbon monoxide fumes upon decomposition. 1-(1-NAPHTHYL)-2-THIOUREA reacts with silver nitrate and strong oxidizers. Avoid decomposing heat.

Safety Profile

Poison by ingestion and intraperitoneal routes. Moderately toxic to humans by an unspecified route. Questionable carcinogen with experimental tumorigenic data. Mutagenic data. A rodenticide used extensively. Death is caused by pulmonary edema. Chronic toxicity has been known to cause dermatitis and a decrease in the white blood cells. When heated to decomposition it emits toxic fumes of NOx and SOx.

Potential Exposure

ANTU or its formulations are used as a rodenticide.

Environmental Fate

Chemical/Physical. The hydrolysis rate constant for ANTU at pH 7 and 25°C was determined to be 8 × 10–5/hour, resulting in a half-life of 361 days (Ellington et al., 1988)
Emits very toxic fumes of nitrogen and sulfur oxides when heated to decomposition (Lewis, 1990)

storage

α-Naphthalene thiourea should be kept stored in a tightly closed container in a locked poison room, in a cool, dry, well-ventilated area away from incompatible substances.

Shipping

UN1651 Naphthylthiourea, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

Purification Methods

Crystallise ANTU from EtOH. [Beilstein 12 III 2941, 12 IV 3086.]

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, silver nitrate.

Waste Disposal

Incinerate in a furnace equipped with an alkaline scrubber. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.

Precautions

Workers should use/handle α-naphthalene thiourea with adequate ventilation. During use, dust generation and accumulation should be minimum, and avoid contact with the eyes, skin, and clothing.

1-(1-NAPHTHYL)-2-THIOUREA Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

1-(1-NAPHTHYL)-2-THIOUREASupplierMore

Alfa Aesar
Tel:
400-610-6006; 021-67582000
Email:
saleschina@alfa-asia.com
T&W GROUP
Tel:
021-61551413- ;021-61551611-
Email:
contact@trustwe.com;contact@trustwe.com
Thermo Fisher Scientific
Tel:
800-810-5118
Email:
cnchemical@thermofisher.com
Shanghai T&W Pharmaceutical Co., Ltd.
Tel:
+86 21 61551611
Email:
contact@trustwe.com
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel:
03-3668-0489
Email:
Sales-JP@TCIchemicals.com
Basic information Safety Related Supplier