β-Nicotinamide Mononucleotide Chemical Properties
- storage temp.
- WGK Germany
β-Nicotinamide Mononucleotide Usage And Synthesis
White to Yellowish lyophilized powder
A product of the extracellular Nicotinamide phosphoribosyltransferase (eNAMPT) reaction and a key NAD+ intermediate. It ameliorates glucose intolerance by restoring NAD+ levels in HFD-induced T2D mice . It also enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation.
β-Nicotinamide mononucleotide (NMN) is used to study binding motifs within RNA aptamers and ribozyme activation processes involving β-nicotinamide mononucleotide (β-NMN)-activated RNA fragments.
Nicotinamide mononucleotide ("NMN" and "β-NMN") is a nucleotide derived from ribose and nicotinamide. Niacinamide (nicotinamide,) is a derivative of vitamin B3, also known as niacin.) As a biochemical precursor of NAD+, it may be useful in the prevention of pellagra.
β-Nicotinamide mononucleotide (β-NMN) is an intermediate in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to generate β-NMN, which is subsequently converted to NAD+ by β-NMN adenyltransferase.At 50-100 µM, β-NMN has been used to enhance NAD biosynthesis and glucose-stimulated insulin secretion in a Nampt+/- mouse model of metabolic disease, demonstrating a role for Nampt in β cell function.Furthermore, at 500 mg/kg/day, it has been shown to ameliorate glucose intolerance in high-fat diet-induced type 2 diabetes mice by restoring NAD+ levels.
A condensation product of nicotinamide and ribose 5-phosphate, in which the nitrogen of nicotinamide is linked to the (β) c-l of the ribose.
Nicotinamide adenine dinucleotide (NAD+)?exists in all living organisms and is well known as a coenzyme in oxidation?reduction reaction. Recent research has drawn attention to its relation to “sirtuin” represented by NAD+?dependent protein deacetylases, which is to regulate various life phenomena as aging, people are especially paying high attention to “Anti-aging effect”. The turnover of the oxidized form of nicotinamide adenine dinucleotide (NAD+) has attracted interest in regard to longevity.?Meanwhile, sirtuin is NAD+?dependent and increase of cellular NAD+?level is expected to have similar effects to the STACs, thus nicotinamide mononucleotide, an intermediate of NAD+?biosynthesis, is also in the spotlight.
Purify NMN by passage through a column of Dowex-1 (Clform) and washing with H2O until no absorbance is observed at 260 nm. The tubes containing NMN are pooled, adjusted to pH 5.5-6 and evaporated in vacuo to a small volume. This is adjusted to pH 3 with dilute HNO3 in an ice-bath and treated with 20volumes of Me2CO at 0-5o. The heavy white precipitate is collected by centrifugation at 0o. It is best stored wet and frozen or it can be dried to give a gummy residue. It has max 266nm ( 4,600) and min 249nm ( 3600) at pH 7.0 (i.e. no absorption at 340nm). It can be estimated by reaction with CNor hydrosulfite which form the 4-adducts (equivalent to NADH) which have UV max 340nm ( 6,200). Thus after reaction, an OD340 of one is obtained from a 0.1612mM solution in a 1cm path cuvette. [Plaut & Plaut Biochemical Preparations 5 56 1957, Maplan & Stolzenbach Methods Enzymol 3 899 1957, Kaplan et al. J Am Chem Soc 77 815 1955, Beilstein 22/2 V 168.]
- Triphosphopyridine nucleotide disodium salt
- BETA-DIPHOSPHOPYRIDINE NUCLEOTIDE HYDRATE, OXIDIZED FORM
- beta-Diphosphopyridine nucleotide
- NADP MONOPOTASSIUM SALT
- NAD3H DIPOTASSIUM SALT
- BETA-DPN LITHIUM SALT
- N6-([6-AMINOHEXYL]-CARBAMOYLMETHYL)-NICOTINAMIDE ADENINE DINUCLEOTIDE LITHIUM SALT
- 1,N6-ETHENO NAD
- Triphosphopyridine nucleotide
- BETA-NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE SODIUM SALT
- β-Nicotinamide adenine dinucleotide phosphate sodium salt
- BETA-NAD TETRAHYDRATE
- NICOTINAMIDE ADENINE DINUCLEOTIDE-AGAROSE
- 2':3'-CYCLIC NADP SODIUM SALT
- NAD 3H2O
- BETA-NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE RESIN
- BETA-NICOTINAMIDE ADENINE DINUCLEOTIDE SODIUM SALT
- 3'-NADP SODIUM SALT
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