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Ethylenebis(oxyethylenenitrilo)tetraacetic acid

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Ethylenebis(oxyethylenenitrilo)tetraacetic acid Basic information

Product Name:
Ethylenebis(oxyethylenenitrilo)tetraacetic acid
CAS:
67-42-5
MF:
C14H24N2O10
MW:
380.35
EINECS:
200-651-2
Mol File:
67-42-5.mol
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Ethylenebis(oxyethylenenitrilo)tetraacetic acid Chemical Properties

Melting point:
241 °C (dec.)(lit.)
Boiling point:
507.99°C (rough estimate)
Density 
1.2838 (rough estimate)
refractive index 
1.4590 (estimate)
storage temp. 
Store at RT.
solubility 
0.1 M NaOH: 0.1 M at 20 °C, clear, colorless
pka
1.47±0.10(Predicted)
form 
Crystalline Powder
color 
White
Water Solubility 
slightly soluble
Merck 
14,3529
BRN 
1717370
CAS DataBase Reference
67-42-5(CAS DataBase Reference)
EPA Substance Registry System
Ethylenebis(oxyethylenenitrilo)tetraacetic acid (67-42-5)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
24/25-36-26
WGK Germany 
2
RTECS 
AH3760000
TSCA 
Yes
HS Code 
29225000
Toxicity
LD50 orally in Rabbit: 3587 mg/kg

MSDS

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Ethylenebis(oxyethylenenitrilo)tetraacetic acid Usage And Synthesis

Description

Ethylenebis(oxyethylenenitrilo)tetraacetic acid is also named as Egtazic acid. It works as a chelating agent for the determination of calcium in the presence of magnesium.

Chemical Properties

White to slightly off-white powder

Uses

Pharmaceutic aid. EGTA.

Definition

ChEBI: A diether that is ethylene glycol in which the hydrogens of the hydroxy groups have been replaced by 2-[bis(carboxymethyl)amino]ethyl group respectively.

Biological Activity

Calcium chelator; protects against cell death caused by nitric oxide-induced calcium influx into nerve cells.

Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of NOx. See also GLYCOL ETHERS.

Purification Methods

Dissolve EGTA in aqueous NaOH, precipitate it by adding aqueous HCl, wash it with water and dry at 100o in vacuo.[Beilstein 4 IV 217.]

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Ethylenebis(oxyethylenenitrilo)tetraacetic acidSupplierMore

Shanghai Worldyang Chemical Co.,Ltd. Gold
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3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801
Email:
3bsc@sina.com
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