ChemicalBook >  Product Catalog >  Flavors and fragrances >  Synthetic fragrances >  Carboxylic acids and esters >  Aliphatic dicarboxylic acid esters >  Dibutyl sebacate

Dibutyl sebacate

Basic information Safety Related Supplier

Dibutyl sebacate Basic information

Product Name:
Dibutyl sebacate
CAS:
109-43-3
MF:
C18H34O4
MW:
314.46
EINECS:
207-395-0
Mol File:
109-43-3.mol
More
Less

Dibutyl sebacate Chemical Properties

Melting point:
205 °C (dec.)(lit.)
Boiling point:
178-179 °C3 mm Hg(lit.)
Density 
0.94
FEMA 
2373 | DIBUTYL SEBACATE
refractive index 
n20/D 1.441(lit.)
Flash point:
>230 °F
solubility 
hexane, toluene, ethanol and acetone: soluble
form 
Liquid
Specific Gravity
0.937 (20/4℃)
color 
Clear
Water Solubility 
50mg/L(temperature not stated)
JECFA Number
625
BRN 
1798308
CAS DataBase Reference
109-43-3(CAS DataBase Reference)
NIST Chemistry Reference
Di-n-butyl sebacate(109-43-3)
EPA Substance Registry System
Dibutyl sebacate (109-43-3)
More
Less

Safety Information

Hazard Codes 
Xn,Xi
Risk Statements 
40-36/37/38
Safety Statements 
36/37-36-26
WGK Germany 
3
RTECS 
VS1150000
TSCA 
Yes
HS Code 
29171390
Hazardous Substances Data
109-43-3(Hazardous Substances Data)
Toxicity
LD50 oral in rat: 14870mg/kg

MSDS

More
Less

Dibutyl sebacate Usage And Synthesis

Chemical Properties

clear liquid

Chemical Properties

Dibutyl sebacate is a clear, colorless, oily liquid with a bland to slight butyl odor.

Uses

Dibutyl sebacate (DBS) is a dibutyl ester of sebacic acid. Dibutyl sebacate can be used for plastics in use in the food packaging industry, in plastics used for medical devices, and for pharmaceutical applications. Dibutyl sebacate is also used as a desensitizer in Otto fuel II, a torpedo monopropellant.

Production Methods

Dibutyl sebacate is manufactured by the esterification of n-butanol and sebacic acid in the presence of a suitable catalyst, and by the distillation of sebacic acid with n-butanol in the presence of concentrated acid.

Preparation

By distillation of sebacic acid with butyl alcohol in the presence of concentrated HCl in benzene solution or by reacting butyl alcohol and sebacyl chloride

Pharmaceutical Applications

Dibutyl sebacate is used in oral pharmaceutical formulations as a plasticizer for film coatings on tablets, beads, and granules, at concentrations of 10–30% by weight of polymer. It is also used as a plasticizer in controlled-release tablets and microcapsule preparations.
Dibutyl sebacate is also used as a synthetic flavor and flavor adjuvant in food products;for example,up to 5ppm is used in ice cream and nonalcoholic beverages.

Safety Profile

Mddly toxic by ingestion. Experimental reproductive effects. Combustible liquid when exposed to heat or flame; can react with oxidzing materials. To fight fire, use CO2 position it emits acrid smoke and fumes. See also ESTERS and n-BUTYL. ALCOHOL.

Safety

Dibutyl sebacate is used in cosmetics, foods, and oral pharmaceutical formulations, and is generally regarded as a nontoxic and nonirritant material. Following oral administration, dibutyl sebacate is metabolized in the same way as fats. In humans, direct eye contact and prolonged or repeated contact with the skin may cause very mild irritation. Acute animal toxicity tests and long-term animal feeding studies have shown no serious adverse effects to be associated with orally administered dibutyl sebacate.
LD50 (rat, oral): 16g/kg

storage

Dibutyl sebacate should be stored in a closed container in a cool, dry location. Dibutyl sebacate is stable under the recommended storage conditions and as used in specified applications under most conditions ofuse.Asanester,dibutylsebacatemayhydrolyzeinthe presence of water at high or low pH conditions.

Incompatibilities

Dibutyl sebacate is incompatible with strong oxidizing materials and strong alkalis.

Regulatory Status

Included in the FDA Inactive Ingredients Database (oral capsules, granules, film-coated, sustained action, and tablets). Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Dibutyl sebacate Preparation Products And Raw materials

Raw materials

More
Less

Dibutyl sebacateSupplierMore

Sichuan Hainuowei Technology Co. Ltd. Gold
Tel:
028-83585582 ,13708085536
Email:
hanovichem@163.com
J & K SCIENTIFIC LTD.
Tel:
010-82848833- ;010-82848833-
Email:
jkinfo@jkchemical.com;market6@jkchemical.com
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel:
21-61259100-
Email:
sh@meryer.com
Alfa Aesar
Tel:
400-610-6006; 021-67582000
Email:
saleschina@alfa-asia.com
TCI (Shanghai) Development Co., Ltd.
Tel:
021-67121386 / 800-988-0390
Email:
Sales-CN@TCIchemicals.com
Basic information Safety Related Supplier