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Chlorpheniramine maleate

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Chlorpheniramine maleate Basic information

Product Name:
Chlorpheniramine maleate
CAS:
113-92-8
MF:
C20H23ClN2O4
MW:
390.86
EINECS:
204-037-5
Mol File:
113-92-8.mol
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Chlorpheniramine maleate Chemical Properties

Melting point:
130-135 °C(lit.)
alpha 
-1~+1°(D/20℃)(c=5,DMF)
Density 
1.1984 (rough estimate)
refractive index 
1.6800 (estimate)
Flash point:
9℃
storage temp. 
-20°C Freezer
solubility 
Freely soluble in water, soluble in ethanol (96 per cent)
form 
neat
PH
4.0~5.5 (10g/l, 25℃)
Water Solubility 
1-5 g/100 mL at 21 ºC
Merck 
14,2180
InChIKey
DBAKFASWICGISY-BTJKTKAUSA-N
EPA Substance Registry System
Chlorpheniramine maleate (113-92-8)
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Safety Information

Hazard Codes 
T,F
Risk Statements 
25-39/23/24/25-23/24/25-11
Safety Statements 
36/37/39-45-36/37-16
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
US6504000
TSCA 
Yes
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29333990
Toxicity
LD50 orally in mice: 162 mg/kg (Smith)

MSDS

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Chlorpheniramine maleate Usage And Synthesis

Chemical Properties

White Solid

Uses

An antagonist of the histamine H1-receptor

Uses

Antihistaminic

brand name

Trimeton (Schering-Plough); Teldrin (GlaxoSmithKline).

General Description

Chlorpheniraminemaleate, (±)2-[p-chloro-α-[2-dimethylamino)ethyl]benzyl]pyridine bimaleate (Chlor-Trimeton), is a white crystallinepowder that is soluble in water (1:3.4), in alcohol(1:10), and in chloroform (1:10). It has a pKa of 9.2, and anaqueous solution has a pH between 4 and 5. Chlorination ofpheniramine in the para position of the phenyl ring increasespotency 10-fold with no appreciable change in toxicity.Most of the antihistaminic activity resides with thedextro isomer (see under “Dexchlorpheniramine Maleate” ).The usual dose is 2 to 4 mg 3 or 4 times a day. It has a halflifeof 12 to 15 hours.

General Description

Odorless white crystalline solid or white powder with a bitter taste. pH (2% aqueous solution) 5. pH (1% aqueous solution) 4-5.

Air & Water Reactions

Water soluble.

Reactivity Profile

A halogenated amine, ester. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.

Fire Hazard

Flash point data for Chlorpheniramine maleate are not available; however, Chlorpheniramine maleate is probably combustible.

Safety Profile

Poison by ingestion, intravenous, and subcutaneous routes. Experimental reproductive effects. Used as an antihistamine. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cland NOx.

Veterinary Drugs and Treatments

Antihistamines are used in veterinary medicine to reduce or help prevent histamine mediated adverse effects. Chlorpheniramine is one the more commonly used antihistamines in the cat for the treatment of pruritus. It may also be of benefit as a mild sedative in small animals due to its CNS depressant effects.

Dosage forms

4 to 6 mg PO q4–6h. Maximum daily dose is 24 mg for adults and children 12 years or older. Found frequently in combination with acetaminophen and pseudoephedrine.

Chlorpheniramine maleate Preparation Products And Raw materials

Raw materials

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Chlorpheniramine maleate SupplierMore

Wuhai Shuou Technology Co., Ltd. Gold
Tel:
17792809151
Email:
2355916837@ycphar.com;2355916837@ycphar.com
Guangzhou Belka Biological Technology Co., Ltd. Gold
Tel:
18665676617
Email:
11353066@qq.com
Zhongxiang Yaowei Biological Technology Co., Ltd. Gold
Tel:
13260682861 153-37241005-
Email:
w13260682861@163.com;516219607@qq.com
Wuhan Biocar Bio-Pharm Co., Ltd. Gold
Tel:
13343428090
Email:
85776233@qq.com
Wuhan Biocar Pharmacy Co.,Ltd Gold
Tel:
13343447621
Email:
1217387561@qq.com
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