tBuXPhos-Pd-G3

Product NametBuXPhos-Pd-G3
CAS1447963-75-8
MFC42H58NO3PPdS
MW794.38
EINECS
MOL File1447963-75-8.mol

Chemical Properties

Melting point	130-140°C
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
form	Powder
color	yellow
InChIKey	KKVLHKIBKWORMK-UHFFFAOYSA-N
SMILES	P(C1C=CC=CC=1C1C(=CC(C(C)C)=CC=1C(C)C)C(C)C)([Pd+2]1(NC2=CC=CC=C2C2=CC=CC=[C-]12)[O-]S(=O)(=O)C)(C(C)(C)C)C(C)(C)C

Safety Information

WGK Germany	3
HS Code	2843909000

Usage And Synthesis

Physical properties

tBuXPhos-Pd-G3 is in the form of a dark grey crystalline powder.

Uses

tBuXPhos Pd G3 may be used to synthesize 4-cyano-7-azaindole from 4-chloro-7-azaindole by cyanation reaction. It may also be used for the α-arylation reaction of acetate esters at room temperature.

Reactions

Mild palladium-catalyzed cyanation of (hetero)aryl halides and triflates in aqueous media.
Reactions of 1447963-75-8

General Description

tBuXPhos Pd G3 is a third generation (G3) Buchwald precatalyst. It is air, moisture and thermally-stable and is highly soluble in a wide range of common organic solvents. It has long life in solutions. tBuXPhos Pd G3 is an excellent reagent for Buchwald-Hartwig cross-coupling reaction. Some of its unique features include lower catalyst loadings, shorter reaction time, efficient formation of the active catalytic species and accurate control of ligand: palladium ratio.

storage

tBuXPhos Pd G3 should be stored in an airtight, dry and low temperature.