ChemicalBook >  Product Catalog >  API >  Circulatory system drugs >  Angina Pectoris Drugs >  Amlodipine

Amlodipine

Basic information Safety Related Supplier

Amlodipine Basic information

Product Name:
Amlodipine
CAS:
88150-42-9
MF:
C26H31ClN2O8S
MW:
567.05
EINECS:
1308068-626-2
Mol File:
88150-42-9.mol
More
Less

Amlodipine Chemical Properties

Melting point:
178-179°C
Boiling point:
527.2±50.0 °C(Predicted)
Density 
1.227±0.06 g/cm3(Predicted)
RTECS 
US7968329
storage temp. 
-20°C Freezer
pka
pKa 8.6 (Uncertain)
form 
Almost white crystal powder
Water Solubility 
75.3 mg/L
CAS DataBase Reference
88150-42-9(CAS DataBase Reference)
EPA Substance Registry System
3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester (88150-42-9)
More
Less

Safety Information

HazardClass 
IRRITANT
HazardClass 
6.1
Toxicity
TDLo orl-chd: 400 mg/kg:BPR AJEMEN 18,581,2000
More
Less

Amlodipine Usage And Synthesis

Chemical Properties

Yellow Solid

Uses

A dihydropyridine calcium channel blocker; activity resides mainly in the (-)-isomer.

Uses

anti-hypertensive;calcium channel blocker

Uses

A deuterated dihydropyridine calcium channel blocker.;Application of Labeled APIs: Labeled Amlodipine, intended for use as an internal standard for the quantification of Amlodipine by GC- or LC-mass spectrometry.

Definition

ChEBI: A fully substituted dialkyl 1,4-dihydropyridine-3,5-dicarboxylate derivative, which is used for the treatment of hypertension, chronic stable angina and confirmed or suspected vasospastic angina.

brand name

Norvasc (Pfizer).

General Description

Amlodipine, 2-[, for the treatment of hypertension. Amlodipineis also marketed as a combination therapy with atorvastatinunder the tradename Norvasc for the management of highcholesterol and high blood pressure.

Hazard

Human systemic effects.

Safety Profile

Human systemic effects. Whenheated to decomposition it emits toxic vapors of NOx andCl-.

More
Less

AmlodipineSupplierMore

Hubei Dingcheng Shijia Pharmaceutical Chemical Co., Ltd. Gold
Tel:
13995602569
Email:
hbdcsjyy@163.com
Shenzhen Kaimingke Biotechnology Co., Ltd. Gold
Tel:
181-26439142-
Email:
1144496688@QQ.COM;
Kono Chem Co.,Ltd Gold
Tel:
29-86107037-8015
Email:
info@konochemical.com
J & K SCIENTIFIC LTD.
Tel:
010-82848833- ;010-82848833-
Email:
jkinfo@jkchemical.com;market6@jkchemical.com
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel:
821-50328103-801
Email:
3bsc@sina.com
Basic information Safety Related Supplier