CAS No:87-33-2
Molecular Formula:C6H8N2O8
Molecular Weight: 236.13
Appearance: Fine white crystal
isosorbide dinitrate Properties
Item | Specifications |
|---|
Appearance | Fine white crystal |
Purity/% | 99.9% |
| Density b(20℃)（kg/m3) | 1700 |
| Melting Point/℃ | 173 |
| Flashpoint/℃ | 186.6 |
| PSA | 128.5 |
| Refractive index | 1.538 |
| solubility | Soluble in chloroform, acetone, slightly soluble in ethanol, slightly soluble in water |
| Mechanical impurities | NO |
isosorbide dinitrate USES
The
clinical application is mainly for the treatment of coronary heart
disease; Prevention of angina; Treatment of persistent angina pectoris
after myocardial infarction; In combination with digitalis and/or
diuretics to treat chronic congestive heart failure; Treatment of
pulmonary hypertension.
The main pharmacological effect of
isosorbide nitrate (ISDN) is to relax vascular smooth muscle. ISDN is
metabolized in the body to produce isosorbide mononitrate (ISMN), which
releases nitric oxide (NO), which is the same as endothelial relaxation
factor, activates guanylate cyclase, increases the cyclic guanylate
(cGMP) in smooth muscle cells, thus relaxing vascular smooth muscle,
dilating peripheral arteries and veins, and having a stronger effect on
venous dilation. Venous dilation results in peripheral blood retention,
reduced cardiac return, left ventricular end-diastolic pressure and
pulmonary capillary wedge pressure (preload). Arterial dilation reduces
peripheral vascular resistance, systolic arterial pressure and mean
arterial pressure (afterload). Coronary artery dilation increases
coronary perfusion volume. The overall effect is to reduce the oxygen
consumption of the heart muscle, increase the oxygen supply, and relieve
angina pectoris.
isosorbide dinitrate Packaging
Packing: 1g，5g，25g/Drum
Belonging to common goods
isosorbide dinitrate Storage
1. Stored in a cool dry place away from direct sunlight and water
2. Separated from oxidants and foodstuffs
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