醋酸格拉替雷是髓鞘碱性蛋白的合成类似物和一种免疫调节剂，可用于多发性硬化症的研究

   Glatiramer acetate 是髓鞘碱性蛋白的合成类似物和一种免疫调节剂，可用于多发性硬化症的研究。Glatiramer acetate 显示出与 MHC 分子强而杂乱的结合，因此与各种髓鞘抗原竞争，使其呈现给T细胞。Glatiramer acetate 作用的另一个方面是有效地诱导T辅助细胞 2 (Th2) 的特异性抑制细胞迁移到大脑并导致原位旁观者抑制。

  体外研究：

   Glatiramer acetate (25-100 mg/kg; S.c; 5 days) increase BDNF levels^[3].
In huntington’s disease (HD) mouse model, the N171-82Q transgenic mouse line, which exhibits a more rapidly progressing disease course. Glatiramer acetate (1 mg/mouse; s.c.; 5×week) beginning at 8 weeks of age and continuing until 20 weeks of age, which is near the age of death due to the disease. Glatiramer acetate elicited improves performance on several motor function measures. Glatiramer acetate significantly improves the performance of N171-82Q transgenic mice at 15 weeks of age in the rotarod test measured over the course of 4 days^[3].