Description
Oxiconazole is a substituted imidazole derivative,it is structurally distinct from miconazole, econazole, clotrimazole, and ketoconazole because it is an acetophene-oxime derivative. It has a broad spectrum of antifungal activity including activity against yeasts, dermatophytes, and Aspergillus species.
Uses
Antifungal.
Oxiconazole (Oxistat) is a synthetic imidazole that works, in part, by inhibiting ergosterol 2,3-epoxidase synthesis and thereby disrupting cell membrane integrity.
Uses
Oxiconazole is used as an antifungal agent.
Indications
Topical treatment of mycoses of the skin induced or sustained by fungi such as dermatophytes and yeasts. In addition, oxiconazole is indicated for therapy of vulvovaginal mycoses caused by Candida species and Candida (Torulopsis) glabrata.
Definition
ChEBI: An oxime O-ether that is the 2,4-dichlorobenzyl ether of the oxime obtained by formal condensation of hydroxylamine with the carbonyl group of acetopnenone in which the phenyl group is substituted by chlorines at positions 2 and 4, and i
which one of the hydrogens of the methyl group is replaced by a 1H-imidazol-1-yl group. An antifungal agent, it is used (generally as the nitrate salt) in creams and powders for the topical treatment of fungal skin infections.
brand name
Oxistat (Altana).
Antimicrobial activity
Broad-specktrum
imidazole antimycotic with activity against almost all species of pathogenic fungi.
Side effects
Local irritations such as itching and burning sensations, and allergic reactions may occur in rare cases and are mainly due to the galenic formulation.
