Chemical Properties
dark brown solution
Uses
Methylmagnesium chloride is used as a Grignard reagent and an alkylating agent in organic synthesis.
Definition
ChEBI: Methylmagnesium chloride is an alkylmagnesium halide and a one-carbon compound. available as a solutionin tetrahydrofuran.
Application
Methylmagnesium chloride solution (3 M in THF) undergoes 1,3-addition with dialdose derived nitrones to form N-benzylhydroxylamines. The reductive cleavage of the N-O bond of these N-benzylhydroxylamines results in N-benzylaminosugars, which are key moieties of bioactive compounds. It can also react with Garner type aldehydes to form the corresponding secondary alcohols.
Preparation
reaction of methyl chloride and magnesium in anhydrous diethyl ether, usually in the presence of an initiator.
Reactions
Methylmagnesium chloride can react with acidic hydrogen on oxygen, sulfur and alkyne carbon of compounds containing active hydrogen (such as water, alcohol, mercaptan, amine, amide, acid, sulfonic acid, etc.); Propyl bromide, etc.) undergoes a coupling reaction; it can react with oxygen and carbon dioxide, aldehydes, ketones, etc.
Hazard
Flammable, dangerous fire and explosionrisk.
