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Isopropyl palmitate

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Isopropyl palmitate Basic information

Product Name:
Isopropyl palmitate
CAS:
142-91-6
MF:
C19H38O2
MW:
298.5
EINECS:
205-571-1
Mol File:
142-91-6.mol
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Isopropyl palmitate Chemical Properties

Melting point:
11-13 °C(lit.)
Boiling point:
160°C 2mm
Density 
0.852 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.438(lit.)
Flash point:
>230 °F
storage temp. 
2-8°C
solubility 
<0.001g/l
form 
neat
Water Solubility 
Not miscible or difficult to mix with water.
BRN 
1786567
InChIKey
XUGNVMKQXJXZCD-UHFFFAOYSA-N
CAS DataBase Reference
142-91-6(CAS DataBase Reference)
NIST Chemistry Reference
Isopropyl palmitate(142-91-6)
EPA Substance Registry System
Isopropyl palmitate (142-91-6)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/38-36/37/38
Safety Statements 
26-36
WGK Germany 
-
RTECS 
RT4900000
TSCA 
Yes
HS Code 
29157090
Hazardous Substances Data
142-91-6(Hazardous Substances Data)

MSDS

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Isopropyl palmitate Usage And Synthesis

Chemical Properties

Clear colorless liquid

Chemical Properties

Isopropyl palmitate is a clear, colorless to pale yellow-colored, practically odorless viscous liquid that solidifies at less than 16°C.

Uses

Pharmaceutic aid (vehicle, oleaginous).

Uses

isopropyl palmitate is an emollient and moisturizer, it also acts as a binder and solvent. Similar to isopropyl myristate, it is produced from the combination of palmitic acid (coconut or palm oil) and isopropyl alcohol. enzymes are able to metabolize this ingredient and studies do not show allergic reactions or toxicity. Some sources indicate comedogenicity potential.

Definition

ChEBI: A fatty acid ester obtained by the formal condensation of carboxy group of palmitic acid with propan-2-ol. Metabolite observed in cancer metabolism.

Production Methods

Isopropyl palmitate is prepared by the reaction of palmitic acid with propan-2-ol in the presence of an acid catalyst. A high-purity material is also commercially available, which is produced by enzymatic esterification at low temperatures.

Pharmaceutical Applications

Isopropyl palmitate is a nongreasy emollient with good spreading characteristics, used in topical pharmaceutical formulations and cosmetics such as: bath oils; creams; lotions; make-up; hair care products; deodorants; lip products; suntan preparations; and pressed powders.
Isopropyl palmitate is an established penetration enhancer for transdermal systems. It has also been used in controlled-release percutaneous films. Table I: Uses of isopropyl palmitate

Safety

Isopropyl palmitate is widely used in cosmetics and topical pharmaceutical formulations, and is generally regarded as a relatively nontoxic and nonirritant material.
LD50 (mouse, IP): 0.1 g/kg

storage

Isopropyl palmitate is resistant to oxidation and hydrolysis, and does not become rancid. It should be stored in a well-closed container, above 16°C, and protected from light.

Regulatory Status

Included in the FDA Inactive Ingredients Database (topical and transdermal preparations). Used in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Isopropyl palmitate Preparation Products And Raw materials

Raw materials

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Isopropyl palmitateSupplierMore

Hubei Jianwen Biomedical Co., Ltd. Gold
Tel:
027-87883343-
Email:
2332576826@qq.com;
Shanghai Boyle Chemical Co., Ltd.
Tel:
Mr Qiu:021-50182298(Demestic market) Miss Xu:021-50180596(Abroad market)
Email:
sales@boylechem.com
J & K SCIENTIFIC LTD.
Tel:
010-82848833- ;010-82848833-
Email:
jkinfo@jkchemical.com;market6@jkchemical.com
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel:
821-50328103-801
Email:
3bsc@sina.com
future industrial shanghai co., ltd
Tel:
400-0066-400;021-60496031
Email:
sales@jonln.com;sales@jonln.com
Basic information Safety Related Supplier