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Ethyl 4,4,4-trifluoroacetoacetate

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Ethyl 4,4,4-trifluoroacetoacetate Basic information

Product Name:
Ethyl 4,4,4-trifluoroacetoacetate
CAS:
372-31-6
MF:
C6H7F3O3
MW:
184.11
EINECS:
206-750-7
Mol File:
372-31-6.mol
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Ethyl 4,4,4-trifluoroacetoacetate Chemical Properties

Melting point:
-39 °C
Boiling point:
129-130 °C(lit.)
Density 
1.259 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.375(lit.)
Flash point:
84 °F
storage temp. 
Flammables area
solubility 
10g/l
pka
7.76±0.10(Predicted)
form 
Liquid
color 
Clear colorless to slightly yellow
Specific Gravity
1.259 (20/4℃)
PH
6.2 (10g/l, H2O, 20℃)
Water Solubility 
10 g/L (20 ºC)
BRN 
608353
InChIKey
OCJKUQIPRNZDTK-UHFFFAOYSA-N
CAS DataBase Reference
372-31-6(CAS DataBase Reference)
NIST Chemistry Reference
Butanoic acid, 4,4,4-trifluoro-3-oxo-, ethyl ester(372-31-6)
EPA Substance Registry System
Ethyl 4,4,4-trifluoroacetoacetate (372-31-6)
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Safety Information

Hazard Codes 
Xn,F,C,Xi
Risk Statements 
10-22-52/53
Safety Statements 
61-16
RIDADR 
UN 3272 3/PG 3
WGK Germany 
2
Hazard Note 
Flammable/Corrosive
TSCA 
T
HazardClass 
3
PackingGroup 
III
HS Code 
29183000

MSDS

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Ethyl 4,4,4-trifluoroacetoacetate Usage And Synthesis

Chemical Properties

Clear liquid

Uses

Intermediate for agro chemicals and pharmaceuticals (mefloquine). Product Data Sheet

Uses

Widely used in the synthetic process of medicine, pesticides and organic intermediate.

Uses

Ethyl 4,4,4-trifluoroacetoacetate is used in the synthesis of fluorinated 2-thiouracil analogs as antithyroid agents.

Ethyl 4,4,4-trifluoroacetoacetate Preparation Products And Raw materials

Raw materials

Preparation Products

4-BROMO-6-(TRIFLUOROMETHYL)PYRIMIDINE5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE-4-CARBONYL CHLORIDE(5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOL-4-YL)METHANAMINE4-(Trifluoromethyl)-2-(methylthio)pyrimidine-5-carboxylic acid ,97%5-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOLE-4-CARBOXAMIDE4-TRIFLUOROMETHYL-QUINOLINE-2-CARBOXYLIC ACID6-Fluoro-4-(trifluoromethyl)quinolin-2-amine ,97%ethyl 2-(methylsulfanyl)-4-(trifluoromethyl)pyrimidine-5-carboxylate4-(Trifluoromethyl)quinoline-2-carbohydrazide ,97%(5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOL-4-YL)METHANOL4-(Trifluoromethyl)quinolin-2-amine5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE-4-CARBOXAMIDE(4-(Trifluoromethyl)quinolin-2-yl)methanol ,97%(6-Fluoro-4-(trifluoromethyl)quinolin-2-yl)methanol ,97%1-PHENYL-5-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBONYL CHLORIDE(1-TERT-BUTYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-4-YL)METHANOL(5-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOL-4-YL)METHANAMINE(5-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOL-4-YL)METHANOL7-HYDROXY-4-(TRIFLUOROMETHYL)COUMARIN4-HYDROXY-2-(METHYLTHIO)-6-(TRIFLUOROMETHYL)PYRIMIDINE4-BROMO-6-FLUORO-2-(TRIFLUOROMETHYL)QUINOLINE1-PHENYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACIDETHYL 2-PHENYL-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE4-MethylpyrimidineETHYL 1-(TERT-BUTYL)-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE4-bromo-2-(trifluoromethyl)quinolineEthyl 6-fluoro-4-(trifluoromethyl)quinoline-2-carboxylate ,97%4-HYDROXY-2-METHYL-6-TRIFLUOROMETHYLPYRIMIDINE2,6-BIS(TRIFLUOROMETHYL)-4-HYDROXYQUINOLINEETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-3-OL2-BROMO-4-(TRIFLUOROMETHYL)QUINOLINE2-Bromo-6-fluoro-4-(trifluoromethyl)quinoline4-HYDROXY-2-(TRIFLUOROMETHYL)QUINOLINEEthyl 3-amino-4,4,4-trifluorocrotonate
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Ethyl 4,4,4-trifluoroacetoacetateSupplierMore

Taizhou Yongfeng Chemical Industry Co., Ltd Gold
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Nanjing Apicci Pharmaceutical Technology Co., Ltd. Gold
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SHANG FLUORO Gold
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