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3-HYDROXY-3-METHYLGLUTARIC ACID

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3-HYDROXY-3-METHYLGLUTARIC ACID Basic information

Product Name:
3-HYDROXY-3-METHYLGLUTARIC ACID
CAS:
503-49-1
MF:
C6H10O5
MW:
162.14
EINECS:
207-971-1
Mol File:
503-49-1.mol
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3-HYDROXY-3-METHYLGLUTARIC ACID Chemical Properties

Melting point:
105-108 °C(lit.)
Boiling point:
120 °C / 13mmHg
Density 
1.2132 (rough estimate)
refractive index 
1.4230 (estimate)
storage temp. 
−20°C
pka
3.95±0.10(Predicted)
Merck 
14,5808
BRN 
1769194
CAS DataBase Reference
503-49-1(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
22-24/25-36-26
WGK Germany 
2
RTECS 
MA3753000
10
HS Code 
29181990
Toxicity
LD50 in mice (g/kg): 7.33 orally; 3.23 i.p. (Savoie, Lupien)

MSDS

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3-HYDROXY-3-METHYLGLUTARIC ACID Usage And Synthesis

Description

Meglutol (β-hydroxy-β-methylglutaric acid; HMG) is a hypolipidemic agent that acts via the inhibition of cholesterol synthesis a t the stage of HMG-CoAreductase, blocking the conversion of HMG-CoA to mevalonate. This conversion is the rate-limiting step in cholesterol biosynthesis and is the point of physiological feedback control; as such, it appears to be the ideal locus of action for a hypolipidemic agent. Investigational compounds that act by this mechanism include the natural products compactin and mevinolin.

Chemical Properties

White Solid

Originator

Aligarh Muslim Univ. (India)

Uses

antihyperlipoproteinemia

Definition

ChEBI: A dicarboxylic acid that is glutaric acid in which one of the two hydrogens at position 3 is substituted by a hydroxy group, while the other is substituted by a methyl group. It has been found to accumulate in urine of patients suffering from HMG-CoA lyase (3-hydroxy-3-methylglutaryl-CoA lyase, EC 4.1.3.4) deficiency. It occurs as a plant metabolite in Crotalaria dura.

brand name

LIPOGLUTAREN

Purification Methods

Recrystallise the acid from diethyl ether/hexane and dry it under avacuum at 60o for 1hour. [Beilstein 3 IV 1166.]

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3-HYDROXY-3-METHYLGLUTARIC ACIDSupplierMore

J & K SCIENTIFIC LTD.
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TCI (Shanghai) Development Co., Ltd.
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Energy Chemical
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LGM Pharma
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Shanghai Hanhong Scientific Co.,Ltd.
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021-54306202-
Email:
info@hanhonggroup.com;info@hanhonggroup.com
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