Ethyl bromoacetate Chemical Properties
- Melting point:
- -38 °C
- Boiling point:
- 159 °C(lit.)
- 1.506 g/mL at 25 °C(lit.)
- vapor pressure
- 2.6 mm Hg ( 25 °C)
- refractive index
- Flash point:
- 118 °F
- storage temp.
- Store below +30°C.
- water: insoluble
- Specific Gravity
- Water Solubility
- Miscible with ethanol, acetone, benzene and ethyl ether. Immiscible with water.
- Stable. Combustible. Incompatible with strong oxidizing agents, water, strong acids.
- CAS DataBase Reference
- 105-36-2(CAS DataBase Reference)
- NIST Chemistry Reference
- Acetic acid, bromo-, ethyl ester(105-36-2)
- EPA Substance Registry System
- Acetic acid, 2-bromo-, ethyl ester (105-36-2)
Ethyl bromoacetate Usage And Synthesis
colourless to light yellow liquid
Ethyl bromoacetate is a clear, colorless to light-yellow liquid.
Ethyl Bromoacetate, is used in the synthesis of metabolites of carcinogenic PAHs. Used in the preparation of steroidal antiestrogens through cyclic condensation. A reactant in the preparation of antim icrobial and antioxidant coumarinyloxymethyl-thiadiazolone.
A clear, colorless liquid (b.p. 318°F). Flash point 47°C. A lachrymator. Toxic by ingestion, inhalation and skin absorption; a strong irritant of the skin. Insoluble in water and soluble in alcohol, benzene, and ether. Specific gravity of 1.5.
Air & Water Reactions
Flammable. Insoluble in water.
Ethyl bromoacetate is a halogenated ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.
Toxic by ingestion, inhalation, and skin absorption; strong irritant.
TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Bromoacetates and chloroacetates are extremely irritating/lachrymators. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.
A poison. An irritant to skin, eyes, and mucous membranes. Questionable carcinogen with experimental neoplastigenic data. Flammable liquid when exposed to heat, flame, and oxidizers. Will react with water or steam to produce toxic and corrosive fumes. To fight fire, use water as a fire blanket. When heated to decomposition or on contact with acid or acid fumes, it emits highly toxic fumes of Br-. See also BROMIDES.
Used for making pharmaceuticals; as a warning gas in poisonous, odorless gasses; as a tear gas
UN1603 Ethyl bromoacetate, Hazard class: 6.1; Labels: 6.1-Poisonous materials.
Wash the ester with saturated aqueous Na2CO3 (three times), 50% aqueous CaCl2 (three times) and saturated aqueous NaCl (twice). Dry with MgSO4, CaCl2 or CaCO3, and distil it. [Beilstein 2 IV 527.] LACHRYMATORY.
Vapor may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, and reducing agents. Esters are generally incompatible with nitrates. Moisture may cause hydrolysis or other forms of decomposition.
Ethyl bromoacetate Preparation Products And Raw materials
- t-Butyl 2-bromo isobutyrate
- Ethyl bromoacetate
- Bromoacetic acid
- Methyl acrylate
- Diethyl ether
- Ethyl phenylacetate
- Ethyl acetate
- Ethyl cyanoacetate
- Ethyl formate
- Ethyl bromodifluoroacetate
- Ethyl propionate
- Dimethyl succinate
- Ethyl chloroacetate
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